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Titolo:
Myasthenia gravis and sleep
Autore:
Stepansky, R; Zeitlhofer, J;
Indirizzi:
Univ Vienna, Neurol Klin, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 a, Neurol Klin, A-1090 Vienna, Austria
Titolo Testata:
WIENER KLINISCHE WOCHENSCHRIFT
fascicolo: 7-8, volume: 113, anno: 2001,
pagine: 285 - 287
SICI:
0043-5325(20010417)113:7-8<285:MGAS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
GER
Soggetto:
CEREBROSPINAL-FLUID; APNEA; DYSFUNCTION; ANTIBODIES; DISORDERS; BRAIN;
Keywords:
myasthenia gravis; REM sleep-related breathing disorder; CNS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Zeitlhofer, J Univ Vienna, Neurol Klin, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 ia
Citazione:
R. Stepansky e J. Zeitlhofer, "Myasthenia gravis and sleep", WIEN KLIN W, 113(7-8), 2001, pp. 285-287

Abstract

In myasthenia gravis respiratory function is often disturbed in the night,especially during REM sleep, despite of normal daytime respiratory function. Nevertheless, nocturnal respiratory problems are rarely diagnosed. Sleepiness, concentration and memory problems can be symptoms of a sleep relatedbreathing disorder. Reports of reduction of REM sleep, memory dysfunction,and detection of acetylcholine receptor (AchR)-antibodies in the cerebrospinal fluid have lead to the hypothesis of a central nervous system involvement in myasthenia gravis. Possible mechanisms are centrally acting AchR-antibodies, unspecifically acting cytokines and hypoxia, possibly the most important influence upon REM sleep reduction and impaired cognitive function. In a patient presenting possible CNS-involvement (cephalea, fatigue, concentration and memory problems), a polysomnographic investigation should therefore be performed to detect a sleep related breathing disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 19:01:04