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Titolo:
Increased plasma adrenomedullin in patients undergoing percutaneous transluminal coronary angioplasty
Autore:
Erol, MK; Genc, Y; Kiziltunc, A; Bozkurt, E; Acikel, M; Yilmaz, M; Senocak, H;
Indirizzi:
Ataturk Univ Hosp, Sch Med, Dept Cardiol & Biochem, TR-25050 Erzurum, Turkey Ataturk Univ Hosp Erzurum Turkey TR-25050 chem, TR-25050 Erzurum, Turkey
Titolo Testata:
SWISS MEDICAL WEEKLY
fascicolo: 3-4, volume: 131, anno: 2001,
pagine: 50 - 53
SICI:
1424-7860(20010127)131:3-4<50:IPAIPU>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL-CELLS; CARDIAC SECRETION; HEART-FAILURE;
Keywords:
adrenomedullin; coronary angioplasty;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Erol, MK Ataturk Univ Hosp, Sch Med, Dept Cardiol, TR-25050 Erzurum, Turkey Ataturk Univ Hosp Erzurum Turkey TR-25050 25050 Erzurum, Turkey
Citazione:
M.K. Erol et al., "Increased plasma adrenomedullin in patients undergoing percutaneous transluminal coronary angioplasty", SWISS MED W, 131(3-4), 2001, pp. 50-53

Abstract

Objectives: adrenomedullin (ADM) production and secretion have been reported in endothelial cells. The present study was designed to assess whether coronary angiography (CA) and percutaneous transluminal coronary angioplasty(PTCA) affect plasma ADM levels. Design and methods: we measured plasma concentrations of ADM using a specific radioimmunoassay method in patients undergoing coronary angiography or PTCA before and after a 5-minute procedure. Patients were divided into three groups; group I: normal coronary angiography group (11 males, 10 females;mean age 55.90 +/- 11.03 yrs), group II: coronary artery disease (CAD), only coronary angiography performed (11 males, 8 females; mean age 60.95 +/- 9.80 yrs), group III: PTCA performed in patients with CAD (35 males, II females; mean age 55.89 rt IO.-FI yrs). Results: the plasma ADM levels and left ventricular end diastolic pressures measured before the procedure were similar in the three groups (p >0.05).plasma ADM levels were 13.98 +/- 2.26, 15.59 +/- 6.70, 17.15 +/- 8.47 pg/ml respectively. ADM levels measured after C:A showed no significant difference in group I (13.75 +/- 1.75 pg/ml) or group II (16.50 +/- 7.18 pg/ml) (p>0.05). A marked elevation was observed in group III with ADM level of 27.31 +/- 12.27 pg/ml after PTCA (p <0.01). The ADM levels observed in group III after PTCA n ere significantly higher than those of group I and group IIafter coronary angiography (p <0.001). Conclusion: the results of our study show an increase of ADM after PTC:A but not after coronary angiography in patients with or without CAD. We thinkthat the increase of ADM levels may be due to cardiac secretion from endothelial and smooth muscle cells following balloon injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 06:43:37