Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Preparation of the controlled-release matrix tablets of theophylline with micronized low-substituted hydroxypropyl cellulose by a fluidized hot-melt granulation method
Autore:
Kojima, M; Nakagami, H;
Indirizzi:
Daiichi Pharmaceut Co Ltd, Pharmaceut Formulat Res Lab, Edogawa Ku, Tokyo 1348630, Japan Daiichi Pharmaceut Co Ltd Tokyo Japan 1348630 a Ku, Tokyo 1348630, Japan Daiichi Pharmaceut Co Ltd, Shizuoka Pharmaceut Res Ctr, Pharmaceut TechnolRes Lab, Kanaya, Shizuoka 4280021, Japan Daiichi Pharmaceut Co Ltd Kanaya Shizuoka Japan 4280021 ka 4280021, Japan
Titolo Testata:
STP PHARMA SCIENCES
fascicolo: 2, volume: 11, anno: 2001,
pagine: 145 - 150
SICI:
1157-1489(200103/04)11:2<145:POTCMT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSTAINED-RELEASE; FORMULATION; ACETAMINOPHEN;
Keywords:
controlled-release matrix tablet; micronized low-substituted hydroxypropyl cellulose; theophylline; fluidized hot-melt granulation method; glycerol esters of fatty acids; hydroxypropyl cellulose;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Kojima, M Daiichi Pharmaceut Co Ltd, Pharmaceut Formulat Res Lab, Edogawa Ku, 16-13 Kita Kasai,1 Chome, Tokyo 1348630, Japan Daiichi Pharmaceut Co Ltd 16-13 Kita Kasai,1 Chome Tokyo Japan 1348630
Citazione:
M. Kojima e H. Nakagami, "Preparation of the controlled-release matrix tablets of theophylline with micronized low-substituted hydroxypropyl cellulose by a fluidized hot-melt granulation method", STP PHARM S, 11(2), 2001, pp. 145-150

Abstract

Micronized low-substituted hydroxypropyl cellulose (LH41), which can be used as a controlled-release matrix carrier, is difficult to use for continuous tabletting due to its poor flowability and packability. We have successfully improved the flowability of LH41 whilst maintaining its original controlled-release function through using the fluidized hot-melt granulation (FHMG) technique. Moreover, the controlled-release matrix tablets have been designed using this granulated LH41. Theophylline was used as a model drug, and LH41 as granulated material via the FHMG method using glycerol esters offatty acids (GEFA) as the core material with a low melting point and hydroxypropyl cellulose (HPC) as a hydrophilic gel-forming substance. The tabletting granules, prepared by the FHMG method, possessed excellent flowability, packability and compressibility properties during continuous tabletting. The drug release rate was influenced not only by the existence of LH41 but by the ratio of three granule components in the matrix tablet: LH41, GEFA and HPC. The results show that the controlled-release tablets can be prepared with standard tabletting machines using LH41 granules prepared by the FHMG method.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:54:37