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Titolo:
Joint testing of mortality and a non-fatal outcome in clinical trials
Autore:
McMahon, RP; Harrell, FE;
Indirizzi:
Univ Maryland Baltimore Cty, Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD 21228 USA Univ Maryland Baltimore Cty Baltimore MD USA 21228 altimore, MD 21228 USA Univ Virginia, Sch Med, Dept Hlth Evaluat Sci, Div Biostat & Epidemiol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA
Titolo Testata:
STATISTICS IN MEDICINE
fascicolo: 8, volume: 20, anno: 2001,
pagine: 1165 - 1172
SICI:
0277-6715(20010430)20:8<1165:JTOMAA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE END-POINTS; BONFERRONI PROCEDURE; DROPOUTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: McMahon, RP Univ Maryland Baltimore Cty, Maryland Psychiat Res Ctr, Dept Psychiat, POB21287, Baltimore, MD 21228 USA Univ Maryland Baltimore Cty POB 21287 Baltimore MD USA 21228 A
Citazione:
R.P. McMahon e F.E. Harrell, "Joint testing of mortality and a non-fatal outcome in clinical trials", STAT MED, 20(8), 2001, pp. 1165-1172

Abstract

The following procedures are proposed for clinical trials of potentially lethal diseases with a nonfatal primary outcome: (i) comparison of treatments on worst-rank scores combining mortality and the non-fatal outcome; (ii) testing first for mortality differences, and then for differences on the worst-rank scoring if there is no significant evidence for mortality differences. Power and control of type I error rate while testing mortality and worst-rank scores by Bonferroni or closed testing procedures are compared. Used together these procedures improve power to detect treatments with favourable effects on both mortality and the designated non-fatal outcome, while reducing the likelihood of declaring that a treatment benefits patients whenundetected adverse effects on mortality are present. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:25:35