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Titolo:
Effect of nucleus pulposus on the neural activity of dorsal root ganglion
Autore:
Takebayashi, T; Cavanaugh, JM; Ozaktay, AC; Kallakuri, S; Chen, CY;
Indirizzi:
Wayne State Univ, Ctr Bioengn, Detroit, MI USA Wayne State Univ Detroit MI USA State Univ, Ctr Bioengn, Detroit, MI USA
Titolo Testata:
SPINE
fascicolo: 8, volume: 26, anno: 2001,
pagine: 940 - 944
SICI:
0362-2436(20010415)26:8<940:EONPOT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; NERVE ROOT; PHOSPHOLIPASE A(2); IN-VITRO; COMPRESSION; NEURONS; SENSITIVITY; HYPOXIA; MODEL; PAIN;
Keywords:
nucleus pulposus; dorsal root ganglion; neural activity; radicular pain; neurophysiologic technique;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Takebayashi, T Sapporo Med Univ, Dept Orthopaed Surg, Chuo Ku, South 1,West 16, Sapporo, Hokkaido 0608543, Japan Sapporo Med Univ South 1,West 16 Sapporo Hokkaido Japan 0608543
Citazione:
T. Takebayashi et al., "Effect of nucleus pulposus on the neural activity of dorsal root ganglion", SPINE, 26(8), 2001, pp. 940-944

Abstract

Study Design. This study was designed to investigate, using neurophysiologic techniques in an in vivo rat model, the effect of application of nucleuspulposus to the nerve root on the neural activity of the dorsal root ganglion and the corresponding receptive fields. Objectives. To assess a further role of the dorsal root ganglion in mechanisms of radicular pain in lumbar disc herniation. Summary of Background Data. It has been suggested that the epidural application of autologous nucleus pulposus without mechanical compression causes nerve root inflammation and related radicular pain in lumbar disc herniation. Concerning the dorsal root ganglion, its mechanical hypersensitivity andpotential for generating ectopic discharges have been reported. However, the effect of autologous nucleus pulposus on the dorsal root ganglion is uncertain. Methods. In adult Sprague-Dawley rats spontaneous neural activity was recorded from the surgically exposed L5 dorsal root using electrophysiologic techniques, and the mechanosensitivity of L5 dorsal root ganglia and corresponding receptive fields on the hind paw were measured using calibrated nylonfilaments. Autologous nucleus pulposus from the tail or fat was implanted at the L5 nerve root. Neural activity was monitored for 6 hours. Results. Spontaneous neural activity in the nucleus pulposus group gradually increased and showed significant differences compared with the fat groupfrom 2.5 to 6 hours after exposure. The mechanosensitivity of the dorsal root ganglia showed significant increases compared with the fat group. Conclusions. After application of nucleus pulposus to the nerve root, the dorsal root ganglion demonstrated increased excitability and mechanical hypersensitivity. These results suggest that nucleus pulposus causes excitatory changes in the dorsal root ganglion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 19:05:50