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Titolo:
The relationship between neutrophils and incisional wound healing
Autore:
Canturk, NZ; Esen, N; Vural, B; Canturk, Z; Kirkali, G; Oktay, G; Solakoglu, S;
Indirizzi:
Kocaeli Univ, Sch Med, Dept Gen Surg, Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey iv, Sch Med, Dept Gen Surg, Kocaeli, Turkey Kocaeli Univ, Sch Med, Dept Physiol, Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey niv, Sch Med, Dept Physiol, Kocaeli, Turkey Kocaeli Univ, Sch Med, Dept Obstet & Gynecol, Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey Med, Dept Obstet & Gynecol, Kocaeli, Turkey Kocaeli Univ, Sch Med, Dept Internal Med, Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey Sch Med, Dept Internal Med, Kocaeli, Turkey Dokuz Eylul Univ, Sch Med, Dept Biochem, Izmir, Turkey Dokuz Eylul Univ Izmir Turkey niv, Sch Med, Dept Biochem, Izmir, Turkey Univ Istanbul, Sch Med, Dept Histol & Embryol, Istanbul, Turkey Univ Istanbul Istanbul Turkey , Dept Histol & Embryol, Istanbul, Turkey
Titolo Testata:
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY
fascicolo: 2, volume: 14, anno: 2001,
pagine: 108 - 116
SICI:
1422-2868(200103/04)14:2<108:TRBNAI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; SMOOTH MUSCLE ACTIN; GRANULOCYTE-COLONY; GROWTH-FACTORS; GM-CSF; ALPHA; MYOFIBROBLASTS; MODULATION; RESPONSES;
Keywords:
cyclophosphamide; granulocyte-macrophage; colony-stimulating factor; neutrophils; wound healing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Canturk, NZ Kocaeli Univ, Sch Med, Dept Surg, TR-41900 Derince, Kocaeli, Turkey Kocaeli Univ Derince Kocaeli Turkey TR-41900 Kocaeli, Turkey
Citazione:
N.Z. Canturk et al., "The relationship between neutrophils and incisional wound healing", SKIN PH APP, 14(2), 2001, pp. 108-116

Abstract

The systemic administration of granulocyte-macrophage colony-stimulating factor (GMCSF) is used clinically to increase circulating neutrophils, but its wound healing effects after intraperitoneal treatment have not been studied yet. We planned to investigate the effect of neutrophils on wound healing under cyclophosphamide and GM-CSF treatment. Forty rats were divided into three groups: control group (group I, n = 12) receiving saline, group II (n = 14) receiving cyclophosphamide and group III (n = 14) receiving GM-CSF. The rats in all groups underwent incisional wounding and were euthanized after 7 days. Blood neutrophil counts and functions, tensile strengths and the hydroxyproline level of skin were determined, and a histopathological evaluation of healing was made. Neutrophil counts and phagocytosis significantly increased in group III and decreased in group II. Although the skin hydroxyproline level did not differ, there was a difference in tensile strength of the wounded skin between group II and group III. The wound score in group II was lower than that in groups III and I. As a result we suggest that systemically given GM-CSF - by increasing the neutrophil count and neutrophil phagocytosis index - can enhance the tensile strength of surgical incisions. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:32:08