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Titolo:
Scratching behavior in various strains of mice
Autore:
Inagaki, N; Nagao, M; Igeta, K; Kawasaki, H; Kim, JF; Nagai, H;
Indirizzi:
Gifu Pharmaceut Univ, Dept Pharmacol, Gifu 5028585, Japan Gifu Pharmaceut Univ Gifu Japan 5028585 t Pharmacol, Gifu 5028585, Japan
Titolo Testata:
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY
fascicolo: 2, volume: 14, anno: 2001,
pagine: 87 - 96
SICI:
1422-2868(200103/04)14:2<87:SBIVSO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PASSIVE CUTANEOUS ANAPHYLAXIS; ITCH-ASSOCIATED RESPONSE; MU-OPIOID RECEPTORS; ATOPIC-DERMATITIS; SUBSTANCE-P; NC/NGA MICE; MAST-CELLS; HISTAMINE; PRURITUS; SKIN;
Keywords:
scratching behavior; histamine; serotonin; substance P; immunoglobulin E; passive cutaneous anaphylaxis; vascular permeability increase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Inagaki, N Gifu Pharmaceut Univ, Dept Pharmacol, 5-6-1 Mitahorahigashi, Gifu 5028585,Japan Gifu Pharmaceut Univ 5-6-1 Mitahorahigashi Gifu Japan 5028585
Citazione:
N. Inagaki et al., "Scratching behavior in various strains of mice", SKIN PH APP, 14(2), 2001, pp. 87-96

Abstract

Scratching behavior was induced in 12 strains of mice and the frequency was compared. An injection of histamine at a dose of 50 nmol induced frequentscratching behavior only in ICR mice, although the same dose of serotonin induced frequent scratching behavior in all strains of mice except for A/J. Histamine (10 nmol), serotonin (1 nmol), substance P (50 nmol) and passivecutaneous anaphylaxis induced significant vascular permeability increase in BALB/c, ICR, ddY and NC/Nga mice. These four stimuli also induced frequent scratching behavior in ICR mice. However, they failed to induce substantial increase in the incidence of scratching in the other three strains, except for ddY, which exhibited a slight but significant increase against substance P injection. These results suggest that the ICR mouse is a good responder for scratching behavior against various stimuli, especially against histamine. Thus ICR mice may be suitable for studying mediators and/or mechanisms for itching. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 08:48:36