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Titolo:
Quantitative analysis of spinel CSF dynamics using magnetic resonance imaging: Experimental and clinical studies
Autore:
Freund, M; Adwan, M; Kooijman, H; Heiland, S; Thomsen, M; Hahnel, S; Jensen, K; Gerner, HJ; Sartor, K;
Indirizzi:
Univ Kliniken Heidelberg, Inst Med Biometrie & Informat, Heidelberg, Germany Univ Kliniken Heidelberg Heidelberg Germany format, Heidelberg, Germany Univ Klin Heidelberg, Abt Ortopad 1, Stiftung Orthopad, Heidelberg, Germany Univ Klin Heidelberg Heidelberg Germany g Orthopad, Heidelberg, Germany Univ Klin Heidelberg, Abt Ortopad 2, Stiftung Orthopad, Heidelberg, Germany Univ Klin Heidelberg Heidelberg Germany g Orthopad, Heidelberg, Germany Philips Med Syst Hamburg, Hamburg, Germany Philips Med Syst Hamburg Hamburg Germany Syst Hamburg, Hamburg, Germany
Titolo Testata:
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
fascicolo: 4, volume: 173, anno: 2001,
pagine: 306 - 314
SICI:
1438-9029(200104)173:4<306:QAOSCD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
GER
Soggetto:
CEREBROSPINAL-FLUID FLOW; POSTTRAUMATIC SYRINGOMYELIA; PULSATIONS; PHYSIOLOGY; MOTION;
Keywords:
cerebrospinal fluid movement; flow model; magnetic resonance imaging; posttraumatic syringomyelia; stenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Freund, M Univ Munster, Inst Klin Radiol, Albert Schweitzer Str 33, D-48129 Munster,Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48129 y
Citazione:
M. Freund et al., "Quantitative analysis of spinel CSF dynamics using magnetic resonance imaging: Experimental and clinical studies", ROFO-F RONT, 173(4), 2001, pp. 306-314

Abstract

Quantitative Analysis of Spinel CSF Dynamics using Magnetic Resonance Imaging: Experimental and Clinical Studies. Purpose: Measurement of the oscillating CSF flow in the spinal canal (SC) of healthy volunteers and in patients with post-traumatic syringomyelia (PTS) using an optimized MRI protocol as well as to determine whether stenosis induced velocity changes are detectable using MRI. Methods: In 68 healthy volunteers quantitative studies of CSF flow in the cervical, thoracic, and lumbar regions were performed. First, an optimized sequence was developed and tested in 19 volunteers using four different flow-encoding velocities (4, 8, 12, 16 cm/s). Secondly, the optimized sequence was employed in 49 volunteers to measure the different CSF patterns in the cervical, thoracic, and lumbar spinal canals (CSC, TSC, LSC). Part three of the study, in which patients with PTS are being examined is still underway. We measured the maximum velocity (cm/s), the pixel area (mm(2)),and the stroke volume (ml/s). Using a flow model the velocities prior to and after compression with 5 different power levels were measured at the stenosis and at a distance of 70 cm. Results: A total of 226 dynamic measurements have been performed - so far 76 in the first part (62=81.5% evaluable) and 150 in the second part - using the optimized sequence and optimalflow velocities. A flow-encoding sequence of 12 cm/s was found best in theCSC and one of 6 cm/s in the TSC and LSC. The maximum velocity in the CSC was 0.95 cm/s with the flow being directed caudal and 0.38 cm/s with the flow being directed cranial. In the TSC the values were 4.7 cm/s and 1.65 cm/s and in the LSC 0.96 cm/s and 0.59 cm/s. The highest velocities were foundat the TSC, which has the smallest diameter compared to the CSC and LSC. In the 4 patients with PTS, the maximum velocities were between 0.09 cm/s and 0.97 cm/s with the flow being directed cranial and between 0.04 cm/s and 1.03 cm/s with the flow being directed caudal. The stroke volumina in the CSC were between 0.1 and 1.23 ml/s (mean: 0.48 ml/s) and 0.2 and 2.45 ml/s (mean: 0.66 ml/s) in the TSC and in the LSC 0.08 ml/s and 0.67 ml/s (mean: 0.29 ml/s). The results of the flow model studies showed an increase of velocity between 2.06 and 4.94 cm/s (mean: 3.31 cm/s) at the stenosis and 1.1 and 1.33 cm/s (mean: 1.23 cm/s) at a distance of 70 cm. Conclusion: Quantitative measurement of the oscillating CSF flow in the entire spinal canal (SC) is possible using an optimized MRI protocol as well as to detect stenosisinduced velocity changes, Due to the high interindividual variability in the data of spinal CSF dynamics, further studies are necessary to collect normal data. The detection of movement of CSF in a post-traumatic spinal cordlesion may alter the therapeutic management.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:13:54