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Titolo:
Noninvasive localized MR quantification of creatine kinase metabolites in normal and infarcted canine myocardium
Autore:
Bottomley, PA; Weiss, RG;
Indirizzi:
Johns Hopkins Univ, Dept Radiol, Div MR Res, Baltimore, MD 21287 USA JohnsHopkins Univ Baltimore MD USA 21287 MR Res, Baltimore, MD 21287 USA Johns Hopkins Univ, Dept Med, Div Cardiol, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 ardiol, Baltimore, MD 21287 USA
Titolo Testata:
RADIOLOGY
fascicolo: 2, volume: 219, anno: 2001,
pagine: 411 - 418
SICI:
0033-8419(200105)219:2<411:NLMQOC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; CORONARY-ARTERY DISEASE; CARDIAC PHOSPHORUS METABOLITES; ENERGY PHOSPHATE-METABOLISM; P-31 NMR-SPECTROSCOPY; HUMAN HEART; FAILURE; SYSTEM; CARDIOMYOPATHY; ISCHEMIA;
Keywords:
animals; heart, MR; heart, MR spectroscopy; magnetic resonance (MR), phsophorus studies; magnetic resonance (MR), spectroscopy; metabolism; myocardium, infarction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Bottomley, PA Johns Hopkins Univ, Dept Radiol, Div MR Res, JHOC-4221,601 NCaroline St, Baltimore, MD 21287 USA Johns Hopkins Univ JHOC-4221,601 N Caroline St Baltimore MD USA 21287
Citazione:
P.A. Bottomley e R.G. Weiss, "Noninvasive localized MR quantification of creatine kinase metabolites in normal and infarcted canine myocardium", RADIOLOGY, 219(2), 2001, pp. 411-418

Abstract

PURPOSE: To develop image-guided spatially localized magnetic resonance (MR) spectroscopy to provide a noninvasive quantitative probe of myocardial creatine kinase (CK) metabolism, and to use it to determine the extent of changes in CK energy metabolism in nonviable infarcted canine myocardium. MATERIALS AND METHODS: Water-referenced localized phosphorus and proton MRspectroscopy were combined in a single protocol to noninvasively measure phosphocreatine (PCr), adenosine triphosphate (ATP), and total of phosphorylated and unphosphorylated creatine (CR) concentrations and pH in the myocardium in six normal dogs and six dogs with surgically induced myocardial infarction. Unphosphorylated creatine and adenosine diphosphate (ADP) levels were calculated. The results were compared with biochemical measurements at postmortem biopsy. RESULTS: Significant reductions in PCr-to-ATP ratios (1.7 +/- 0.3 [SD] vs 1 +/- 0.4; P < .001), PCr (10.3 +/- 2.1 vs 4.3 +/- 2.0 mu mol/g wet weight;P < .0001), ATP (6.4 +/- 1.4 vs 3.7 +/- 1.4 mu mol/g wet weight; P < .001), and CR (24.7 +/- 6.1 vs 6.3 +/- 3.7; P < .0001) were measured noninvasively in infarcted, as compared with normal, tissue. Biopsy measurements confirmed infarct-related reductions observed at MR spectroscopy, although high-energy phosphate concentrations were lower at biopsy. ADP calculated from noninvasive MR spectroscopic measurements was 0.11 +/- 0.07 mu mol/g wet weight in normal myocardium. CONCLUSION: This combined phosphorus and proton MR spectroscopic approach provides a near-complete picture of in vivo myocardial CK metabolism in normal and diseased heart and a tool for noninvasively measuring metabolite reductions associated with the loss of viability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:07:58