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Titolo:
The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction
Autore:
Maharajan, P; Maharajan, V; Ravagnan, G; Paino, G;
Indirizzi:
CNR, Inst Cybernet, I-80072 Arco, Naples, Italy CNR Arco Naples Italy I-80072 Inst Cybernet, I-80072 Arco, Naples, Italy CNR, Inst Expt Med, I-00133 Rome, Italy CNR Rome Italy I-00133CNR, Inst Expt Med, I-00133 Rome, Italy Univ Naples Federico II, Fac Vet Med, Dept Struct Funct & Biol Technol, I-80137 Naples, Italy Univ Naples Federico II Naples Italy I-80137 hnol, I-80137 Naples, Italy
Titolo Testata:
PROGRESS IN NEUROBIOLOGY
fascicolo: 3, volume: 64, anno: 2001,
pagine: 269 - 276
SICI:
0301-0082(200106)64:3<269:TWMMAM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANTIA-NIGRA; RECEPTOR AUTORADIOGRAPHY; TARGETED DISRUPTION; NEUROTROPHIC FACTOR; OPIOID RECEPTORS; BASAL GANGLIA; NEURONS; MICE; RAT; BRAIN;
Keywords:
dopamine; dopamine receptors; weaver mutant; substantia nigra; striatum; drug addiction;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Maharajan, V CNR, Inst Cybernet, I-80072 Arco, Naples, Italy CNR Arco Naples Italy I-80072 t, I-80072 Arco, Naples, Italy
Citazione:
P. Maharajan et al., "The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction", PROG NEUROB, 64(3), 2001, pp. 269-276

Abstract

Dopaminergic neurons and their projection-systems are important in some fundamental human activities like locomotion, feeding and sex, essential for survival and procreation, and are relevant to pathologies like Parkinson's disease and drug abuse. Three main dopaminergic projection-systems, namely the nigrostriatal, mesocortical and mesolimbic pathways are the major targets of the neuropharmacological actions of psychomotor stimulants such as cocaine and amphetamine. Studies on knockout mice for dopamine or its receptors provide substantial information but fail to reveal the role of individual dopaminergic projection-systems. Mutant animals with defects specific to one or more projection-systems might be useful for studying the role of individual dopaminergic projection-systems. We propose the weaver mutant mouse, with a defective nigrostriatal dopaminergic projection-system and dopamine depletion in the dorsal striatum but with intact mesocorticolimbic projection-systems, as a suitable model to study the role of individual dopaminergic systems in diverse biological processes including Parkinson's disease and drug abuse. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:18:55