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Titolo:
Subtle differences in the discriminative stimulus effects of cocaine and GBR-12909
Autore:
Tella, SR; Goldberg, SR;
Indirizzi:
Georgetown Univ, Med Ctr, Dept Pharmacol, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 armacol, Washington, DC 20007 USA NIDA, Preclin Pharmacol Sect, Behav Neurosci Branch, Intramural Res Program,NIH, Baltimore, MD USA NIDA Baltimore MD USA nch, Intramural Res Program,NIH, Baltimore, MD USA
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 639 - 656
SICI:
0278-5846(200104)25:3<639:SDITDS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
A 20-ALPHA-BENZOATE BINDING; MONOAMINE UPTAKE INHIBITORS; DOPAMINE RECEPTOR SUBTYPES; TRANSPORTER KNOCKOUT MICE; RHESUS-MONKEYS; INTRAVENOUS COCAINE; LOCAL-ANESTHETICS; PHARMACOLOGICAL CHARACTERIZATION; SODIUM-CHANNELS; D-AMPHETAMINE;
Keywords:
cocaine; discriminative stimulus; dopamine transporter; sodium channels;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Tella, SR Georgetown Univ, Med Ctr, Dept Pharmacol, C405,Med Dent Bldg,3900 Reservoir Rd NW, Washington, DC 20007 USA Georgetown Univ C405,Med Dent Bldg,3900 Reservoir Rd NW Washington DC USA 20007
Citazione:
S.R. Tella e S.R. Goldberg, "Subtle differences in the discriminative stimulus effects of cocaine and GBR-12909", PROG NEUR-P, 25(3), 2001, pp. 639-656

Abstract

1. In addition to inhibiting the dopamine transporter, cocaine affects a variety of other neurotransmitter systems. In the present study, the involvement of both dopaminergic and the nondopaminergic systems in the behavioraleffects of cocaine was studied using an intravenous drug discrimination procedure.2. One group (Group 1) of rats were trained to discriminate cocaine (1 mg/kg, i.v.) from saline, while a second group (Group 2) of rats were trained to discriminate the same dose of cocaine from both GBR-12909 (1 mg/kg i.v.), a dopamine-selective uptake inhibitor, and saline.3. Following training, substitution tests with different doses of cocaine and several drugs pharmacologically related to cocaine were conducted. Whencocaine dose was varied, there was a dose-dependent generalization to the cocaine-training stimulus in both groups of rats. Conversely, GBR-12909 andGBR-12935, another dopamine-selective uptake inhibitor, generalized to thecocaine-training stimulus in Group 1, but there was minimal or no generalization in Group 2.4. The norepinephrine-selective uptake inhibitors, desipramine and nisoxetine, and the serotonin-selective uptake inhibitor, zimeldine, produced little or no generalization to the cocaine-training stimulus in either group ofrats. The sodium channel blocker, dimethocaine which has a relatively highaffinity for the dopamine transporter fully generalized to the cocaine stimulus in both groups of rats, while procaine which has a low affinity for the dopamine transporters only partially generalized to the cocaine-trainingstimulus in both groups of rats.5. Finally, lidocaine, which has negligible affinity for the dopamine transporter, did not generalize to the cocaine-training stimulus in either group of rats. The findings suggest similarities as well as subtle, but important, differences between the discriminative stimulus effects of cocaine and the dopamine uptake inhibitors, GBR-12909 and GBR12935.

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Documento generato il 12/07/20 alle ore 09:19:05