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Titolo:
Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat
Autore:
OLoinsigh, ED; Boland, G; Kelly, JP; OBoyle, KM;
Indirizzi:
Natl Univ Ireland Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Pharmacol, Dublin 4, Ireland Natl Univ Ireland Univ Coll Dublin Dublin Ireland 4 l, Dublin 4, Ireland Royal Coll Surg Ireland, Dublin 2, Ireland Royal Coll Surg Ireland Dublin Ireland 2 Surg Ireland, Dublin 2, Ireland Natl Univ Ireland, Dept Pharmacol, Galway, Ireland Natl Univ Ireland Galway Ireland eland, Dept Pharmacol, Galway, Ireland
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 621 - 638
SICI:
0278-5846(200104)25:3<621:BHANEO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT NERVE-TERMINALS; IN-VIVO EVIDENCE; MDMA ECSTASY; METHYLENEDIOXYMETHAMPHETAMINE MDMA; METHYLENEDIOXYAMPHETAMINE MDA; PARA-CHLOROAMPHETAMINE; BODY-TEMPERATURE; BRAIN; DEGENERATION; 3,4-METHYLENEDIOXYAMPHETAMINE;
Keywords:
behaviour; dopamine; hyperthermia; [H-3]monoamine release; MDA; MDBA; MDEA; MDMA; neurotoxicity; [H-3]paroxetine; serotonin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: O'Boyle, KM Natl Univ Ireland Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Pharmacol, Dublin 4, Ireland Natl Univ Ireland Univ Coll Dublin Dublin Ireland 4 Ireland
Citazione:
E.D. O'Loinsigh et al., "Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat", PROG NEUR-P, 25(3), 2001, pp. 621-638

Abstract

1. The ability of N-ethyl (MDEA) and N-butyl (MDBA) analogues of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') to induce acute behavioural changes and increases in body temperature, and to cause serotonergic neurotoxicity, was assessed in young adult male Wistar rats. The in vitro ability of MDMA analogues to evoke presynaptic monoamine release from crude rat forebrain synaptosomal preparations pre-labelled with [H-3]5-HT or [H-3]DA was also measured.2. In behavioural experiments, acute MDMA and MDEA (20 mg/kg, i.p.) significantly increased rat open-field locomotion scores, decreased open-field rearing, and induced stereotypy, Straub tail and head weaving. MDBA did not produce any of these behaviours.3. After repeated dosing (8 x 20 mg/kg, i.p,, twice daily for 4 days), MDMA > MDEA >> MDBA greater than or equal to saline at decreasing forebrain [H-3]paroxetine binding levels and concentrations of 5-HT and 5-HIAA at 14 days post-treatment. None of the analogues caused any long-term changes in dopamine or noradrenaline concentrations in the forebrain.4. Acute MDMA and MDEA (20 mg/kg, i.p.) produced significant acute increases in rat aural temperature compared with saline-treated animals, while 20 mg/kg MDBA caused no significant effects.5. MDA, MDMA and MDEA were equipotent at inducing [H-3]5-HT release from frontal cortex/hippocampal synaptosomes, while MDBA only evoked a significant release at 100 muM concentrations. The potency order for inducing [H-3]DArelease from striatal synaptosomes was MDA > MDMA > MDEA = MDBA.6. This study shows that large N-alkyl substitution decreases the ability of MDMA analogues to evoke presynaptic 5-HT and DA release, induce acute hyperthermia, hyperlocomotion and behavioural changes, and cause long-term serotonergic neurotoxicity.7. The structure-activity relationship data presented here indicate that the neurotoxic damage caused by substituted amphetamines requires a combination of acute hyperthermia and increased neurotransmitter release. Inductionof one of these effects in isolation is not sufficient to cause serotonergic nerve terminal degradation.

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Documento generato il 25/01/20 alle ore 15:54:04