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Titolo:
The psychopharmacology-molecular biology interface: Exploring the behavioural roles of dopamine receptor subtypes using targeted gene deletion ('knockout')
Autore:
Waddington, JL; Clifford, JJ; McNamara, FN; Tomiyama, K; Koshikawa, N; Croke, DT;
Indirizzi:
Royal Coll Surg Ireland, Dept Clin Pharmacol, Dublin, Ireland Royal Coll Surg Ireland Dublin Ireland Clin Pharmacol, Dublin, Ireland Royal Coll Surg Ireland, Dept Biochem, Dublin, Ireland Royal Coll Surg Ireland Dublin Ireland d, Dept Biochem, Dublin, Ireland Nihon Univ, Sch Dent, Dept Pharmacol, Tokyo 101, Japan Nihon Univ Tokyo Japan 101 v, Sch Dent, Dept Pharmacol, Tokyo 101, Japan
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 925 - 964
SICI:
0278-5846(200105)25:4<925:TPBIET>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-1A-DEFICIENT MUTANT MICE; EEL ANGUILLA-ANGUILLA; WILD-TYPE MICE; D1 RECEPTOR; DEFICIENT MICE; D-3 RECEPTORS; LOCOMOTOR-ACTIVITY; PARKINSONS-DISEASE; TOPOGRAPHICAL EVALUATION; DROSOPHILA-MELANOGASTER;
Keywords:
behavioural regulation; dopamine; D-1-like receptors; D-2-like receptors; dopamine receptor subtypes; 'knockout'; targeted gene deletion;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
128
Recensione:
Indirizzi per estratti:
Indirizzo: Waddington, JL Royal Coll Surg Ireland, Dept Clin Pharmacol, St Stephens Green, Dublin, Ireland Royal Coll Surg Ireland St Stephens Green Dublin Ireland
Citazione:
J.L. Waddington et al., "The psychopharmacology-molecular biology interface: Exploring the behavioural roles of dopamine receptor subtypes using targeted gene deletion ('knockout')", PROG NEUR-P, 25(4), 2001, pp. 925-964

Abstract

1. In the absence of selective agonists and antagonists able to discriminate between individual members of the D-1-like and D-2-like families of dopamine receptor subtypes, functional parcellation has remained problematic.2. 'Knockout' of these subtypes by targeted gene deletion offers a new approach to evaluating their roles in the regulation of behaviour.3. Like any new technique, 'knockout' has associated with it a number of methodological limitations that are now being addressed in a systematic manner.4. Studies on the phenotype of D-1A/1, D-1B/5, D-2, D-3 and D-4 'knockouts' at the level of spontaneous and agonist/antagonist-induced behaviour are reviewed, in terms of methodological issues, neuronal implications and potential clinical relevance.5. Dopamine receptor subtype 'knockout' is a nascent technology that is now beginning to fulfil its potential. It is being complemented by more systematic phenotypic characterisation at the level of behaviour and additional,molecular biologically-based approaches.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:51:27