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Titolo:
Abnormal neurochemical asymmetry in the temporal lobe of schizophrenia
Autore:
Shirakawa, O; Kitamura, N; Lin, XH; Hashimoto, T; Maeda, K;
Indirizzi:
Kobe Univ, Sch Med, Dept Psychiat & Neurol, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 l, Chuo Ku, Kobe, Hyogo 6500017, Japan
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 867 - 877
SICI:
0278-5846(200105)25:4<867:ANAITT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; PLANUM TEMPORALE; MAGNETIC-RESONANCE; RECEPTOR-BINDING; VOLUME; MRI; HIPPOCAMPUS; POSTMORTEM; REVERSAL; DISORDER;
Keywords:
asymmetry; lateralization; neuroanatomy; neurochemistry; planum temporale; schizophrenia; serotonin; superior temporal gyrus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Shirakawa, O Kobe Univ, Sch Med, Dept Psychiat & Neurol, Chuo Ku, 7-5-1 Kusunoki Cho, Kobe, Hyogo 6500017, Japan Kobe Univ 7-5-1 Kusunoki Cho Kobe Hyogo Japan 6500017 , Japan
Citazione:
O. Shirakawa et al., "Abnormal neurochemical asymmetry in the temporal lobe of schizophrenia", PROG NEUR-P, 25(4), 2001, pp. 867-877

Abstract

1. Neuroanatomical asymmetries are known to be present in the human brain,and loss of reversal of these asymmetries, particularly through changes inthe left temporal lobe, have been found in the brains of patients with schizophrenia.2. In addition to disturbed neuroanatomical asymmetries, disturbed neurochemical asymmetries have also been reported in the brains of patients with schizophrenia. However, in the temporal lobe, the laterality of most of these neurochemical changes has not been specifically evaluated. Few neurochemical studies have addressed left-right differences in the superior temporal gyrus (STG).3. A deteriorated serotonin2A receptor-G protein q alpha (Gq alpha)-phosphoinositide-specific phospholipase C beta1(PLC beta1) cascade has been foundin the left, but not right, STG of patients with schizophrenia.4. Not only neuroanatomical but also neurochemical evidence supports the loss or reversal of normal asymmetry of the temporal lobe in schizophrenia, which might be due to a disruption of the neurodevelopmental processes involved in hemispheric lateralization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:52:10