Catalogo Articoli (Spogli Riviste)

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Titolo:
The role of the brain reward system in depression
Autore:
Naranjo, CA; Tremblay, LK; Busto, UE;
Indirizzi:
Univ Toronto, Sunnybrook Womens Coll Hlth Sci Ctr, Psychopharmacol Res Program, Dept Pharmacol, Toronto, ON M4N 3M5, Canada Univ Toronto Toronto ON Canada M4N 3M5 macol, Toronto, ON M4N 3M5, Canada Univ Toronto, Sunnybrook Womens Coll Hlth Sci Ctr, Psychopharmacol Res Program, Dept Psychiat, Toronto, ON M4N 3M5, Canada Univ Toronto Toronto ON Canada M4N 3M5 chiat, Toronto, ON M4N 3M5, Canada Univ Toronto, Sunnybrook Womens Coll Hlth Sci Ctr, Psychopharmacol Res Program, Dept Med, Toronto, ON M4N 3M5, Canada Univ Toronto Toronto ON CanadaM4N 3M5 t Med, Toronto, ON M4N 3M5, Canada Univ Toronto, Sunnybrook Womens Coll Hlth Sci Ctr, Psychopharmacol Res Program, Dept Pharmaceut Sci, Toronto, ON M4N 3M5, Canada Univ Toronto Toronto ON Canada M4N 3M5 t Sci, Toronto, ON M4N 3M5, Canada
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 781 - 823
SICI:
0278-5846(200105)25:4<781:TROTBR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MILD STRESS; INTRACRANIAL SELF-STIMULATION; CONDITIONED PLACE PREFERENCE; MEDIAL PREFRONTAL CORTEX; VENTRAL TEGMENTAL AREA; POSITRON-EMISSION-TOMOGRAPHY; PROGRESSIVE RATIO SCHEDULE; SEROTONIN REUPTAKE INHIBITORS; PRIMATE ORBITOFRONTAL CORTEX; NUCLEUS-ACCUMBENS DOPAMINE;
Keywords:
amphetamine; anhedonia; brain reward system; depression; dopamine; major depressive disorder;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
275
Recensione:
Indirizzi per estratti:
Indirizzo: Naranjo, CA Univ Toronto, Sunnybrook Womens Coll Hlth Sci Ctr, Psychopharmacol Res Program, Dept Pharmacol, Sunnybrook Campus,2075 Bayview Ave,Room F-327, Toronto, ON M4N 3M5, Canada Univ Toronto Sunnybrook Campus,2075 Bayview Ave,Room F-327 Toronto ON Canada M4N 3M5
Citazione:
C.A. Naranjo et al., "The role of the brain reward system in depression", PROG NEUR-P, 25(4), 2001, pp. 781-823

Abstract

1. The goal of this review is to familiarize the reader about the potential involvement of the brain reward system (BRS) in symptoms of Major Depressive Disorder (MDD). The authors introduce a novel approach to study the pathophysiology of MDD that includes pharmacological probing of BRS pathways (e.g. d-amphetamine, hydromorphone) together with an elicited and measurablebehavioral component (e.g. pleasant effects, increased energy, altered cognition).2. To this date, the major focus of MDD pathophysiology studies has been to characterize biological differences between healthy subjects and depressed patients such as alteration in the monoaminergic and endocrine systems. The relative importance of the various biological changes has not been elucidated, that is, linking these with specific behavioral manifestations in MDD have rarely been attempted.3. One core symptom of MDD is a decreased experience of pleasure or interest in previously enjoyed activities (i.e. anhedonia) such as work or hobbies, and is accompanied by decreased motivation or drive. The BRS consists ofthe neural pathways involved in eliciting rewarding experiences in animalsand humans.4. The hypothesis is that altered BRS function may be an underlying brain mechanism of the loss of pleasure/interest experienced in MDD, and will be manifested through an altered response to a BRS probe. The authors have examined BRS function in MDD by introducing a pharmacological probe (i.e. d-amphetamine/d-amph). Amphetamine is defined as a probe due to its ability to release dopamine within major components of the BRS (i.e. the mesocorticolimbic dopamine system. ) In addition to the objective pharmacological effects(e.g, altered heart rate), BRS probes like d-amph elicit reliable and measurable behavior, that is, the hedonic effects.5. A review of the neurobiology of MDD, the BRS, the rationale for implicating the BRS in depressive symptoms, and preliminary data, are presented inthis article.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:33:53