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Titolo:
Thyroid hormone receptor expression in rat placenta
Autore:
Leonard, AJ; Evans, IM; Pickard, MR; Bandopadhyay, R; Sinha, AK; Ekins, RP;
Indirizzi:
Univ Coll London, Sch Med, Div Mol Endocrinol, London W1N 8AA, England Univ Coll London London England W1N 8AA ocrinol, London W1N 8AA, England
Titolo Testata:
PLACENTA
fascicolo: 4, volume: 22, anno: 2001,
pagine: 353 - 359
SICI:
0143-4004(200104)22:4<353:THREIR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
3'-TRIIODO-L-THYRONINE BINDING-SITES; HUMAN-FETAL BRAIN; MATERNAL HYPOTHYROXINEMIA; CONGENITAL HYPOTHYROIDISM; TRIIODOTHYRONINE BINDING; NUCLEOTIDE-SEQUENCE; GENE-EXPRESSION; FIRST-TRIMESTER; EARLY-PREGNANCY; NERVOUS-SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Sinha, AK Univ Coll London, Sch Med, Div Mol Endocrinol, Mortimer St, London W1N 8AA, England Univ Coll London Mortimer St London England W1N 8AA AA, England
Citazione:
A.J. Leonard et al., "Thyroid hormone receptor expression in rat placenta", PLACENTA, 22(4), 2001, pp. 353-359

Abstract

The expression of c-erbA alpha and -beta encoded thyroid hormone receptors(TR) mas investigated in rat placenta between 16 and 21 days of gestation (dg), and in fetal liver and brain at 16 dg, using semi-quantitative RT-PCRand nuclear 3,5,3'-triiodothyronine. (T-3) binding. TR alpha1, TR beta1, c-erbA alpha2 and c-erbA alpha3 mRNA abundance was unchanged in placenta between 16 and 21 dg, as was the dissociation constant (K-d) of T-3 binding. The maximal T-3 binding capacity (B-max) in placenta doubled over this period, suggesting placental TR binding activity is post-transcriptionally regulated. Transcript abundance in tissues at 16 dg can be summarized: TR alpha1, placenta=fetal liver<fetal brain; TR<beta>1, placenta=fetal: liver>fetal brain; c-erbA alpha2 and alpha3, placenta=fetal liver<fetal blain; TR<beta>2; none detected. T-3 binding in fetal liver and brain exhibited equivalentK-d and B-max the K-d being less than 50 per cent of that in placenta, though B-max was unchanged. The higher K-d in placenta may reflect tissue-specific patterns of TR modification. In conclusion, rat placenta expresses significant levels of c-erbA alpha and -beta transcripts and protein, providing a possible mechanism of action for T-3 of maternal and fetal origin in this tissue. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 08:54:56