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Titolo:
Developmental expression of vascular endothelial growth factor (VEGF) receptors and VEGF binding in ovine placenta and fetal membranes
Autore:
Bogic, LV; Brace, RA; Cheung, CY;
Indirizzi:
Univ Calif San Diego, Dept Reprod Med, Div Perinatal Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 al Med, La Jolla, CA 92093 USA
Titolo Testata:
PLACENTA
fascicolo: 4, volume: 22, anno: 2001,
pagine: 265 - 275
SICI:
0143-4004(200104)22:4<265:DEOVEG>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASE; GENE-EXPRESSION; FLT-1 RECEPTOR; AMNIOTIC-FLUID; KDR; LOCALIZATION; CELLS; TISSUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Cheung, CY Univ Calif San Diego, Dept Reprod Med, Div Perinatal Med, 9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 3 USA
Citazione:
L.V. Bogic et al., "Developmental expression of vascular endothelial growth factor (VEGF) receptors and VEGF binding in ovine placenta and fetal membranes", PLACENTA, 22(4), 2001, pp. 265-275

Abstract

The receptor tyrosine kinases, kinase-insert domain-containing receptor (I(DR) and fms-like tyrosine kinase (Flt-1), and their ligand vascular endothelial growth factor (VEGF) are essential for the development and maintenance of placental vascular function during pregnancy. To further understand the role of VEGF in mediating angiogenesis and vascular permeability during development. the cellular localization of KDR and Flt-1 mRNA and protein, and the distribution of I-125-VEGF binding sites in placenta, chorion and amnion of ovine Fetuses were examined at three different gestational ages. In placentae at 62, 103 and 142 days, the predominant site of KDR mRNA and protein, and VEGF binding was the maternal vascular endothelium. In addition, a specific, although weak, signal for KDR mRNA was found in the maternal epithelium. At 103 and 142 days but not 62 days gestation, KDR mRNA and protein as well as VEGF binding sites were abundantly present in the endotheliumof villous blood vessels. In the fetal membranes at 61, 103 and 142 days gestation, KDR mRNA and protein were expressed in the amniotic epithelium and intramembranous blood vessel endothelium. where binding of I-125-VEGF wasstrong. There was no KDR mRNA or VEGF binding in the chorionic cytotrophoblast. Flt-1 expression nas not detectable in placentae or fetal membranes at the three ages studied. In summary, the results demonstrated that VEGF receptors are present in the maternal and fetal vasculatures of the ovine placenta. This expression isconsistent with a capillary growth-promoting function of I;DR and its ligand VEGF. Further, the presence of KDR and VEGF binding sites in ovine fetalmembranes suggests a role for VEGF in promoting intramembranous vascularity and permeability throughout gestation. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:33:56