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Titolo:
In vivo brain tumor demarcation using optical spectroscopy
Autore:
Lin, WC; Toms, SA; Johnson, M; Jansen, ED; Mahadevan-Jansen, A;
Indirizzi:
Vanderbilt Univ, Dept Biomed Engn, Stevenson Ctr 5801, Nashville, TN 37235USA Vanderbilt Univ Nashville TN USA 37235 n Ctr 5801, Nashville, TN 37235USA Vanderbilt Univ, Dept Neurol Surg, Nashville, TN 37235 USA Vanderbilt Univ Nashville TN USA 37235 urol Surg, Nashville, TN 37235 USA Vanderbilt Univ, Dept Pathol, Nashville, TN 37235 USA Vanderbilt Univ Nashville TN USA 37235 pt Pathol, Nashville, TN 37235 USA
Titolo Testata:
PHOTOCHEMISTRY AND PHOTOBIOLOGY
fascicolo: 4, volume: 73, anno: 2001,
pagine: 396 - 402
SICI:
0031-8655(200104)73:4<396:IVBTDU>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT GLIOMAS; FLUORESCENCE SPECTROSCOPY; INTRINSIC FLUORESCENCE; RESECTION; TISSUE; AUTOFLUORESCENCE; IMPACT; EXTENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, WC Vanderbilt Univ, Dept Biomed Engn, Stevenson Ctr 5801, POB 351631,Stn B, Nashville, TN 37235 USA Vanderbilt Univ POB 351631,Stn B Nashville TN USA 37235 37235 USA
Citazione:
W.C. Lin et al., "In vivo brain tumor demarcation using optical spectroscopy", PHOTOCHEM P, 73(4), 2001, pp. 396-402

Abstract

The applicability of optical spectroscopy for intraoperative detection of brain tumors/tumor margins was investigated in a pilot clinical trial consisting of 26 brain tumor patients. The results of this clinical trial suggest that brain tumors and infiltrating tumor margins (ITM) can be effectivelyseparated from normal brain tissues in viva using combined autofluorescence and diffuse-reflectance spectroscopy. A two-step empirical discriminationalgorithm based on autofluorescence and diffuse reflectance at 460 and 625nm was developed. This algorithm yields a sensitivity and specificity of 100 and 76%, respectively, in differentiating ITM from normal brain tissues. Blood contamination was found to be a major obstacle that attenuates the accuracy of brain tumor demarcation using optical spectroscopy. Overall, this study indicates that optical spectroscopy has the potential to guide brain tumor resection intraoperatively with high sensitivity.

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Documento generato il 02/12/20 alle ore 15:08:27