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Titolo:
Pimozide, like extinction, devalues stimuli associated with sucrose taking
Autore:
Johnston, LD; Beninger, RJ; Olmstead, MC;
Indirizzi:
Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 chol, Kingston, ON K7L 3N6, Canada Queens Univ, Dept Psychiat, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 hiat, Kingston, ON K7L 3N6, Canada
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 68, anno: 2001,
pagine: 583 - 590
SICI:
0091-3057(200103)68:3<583:PLEDSA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; 6-HYDROXYDOPAMINE LESIONS; REINFORCER DEVALUATION; BLOCKS ESTABLISHMENT; FOOD REINFORCEMENT; DOPAMINE NEURONS; ACID LESIONS; RATS; REWARD; HALOPERIDOL;
Keywords:
dopamine; reward; operant responding; conditioned reinforcement; devaluation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Olmstead, MC Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 n, ON K7L 3N6, Canada
Citazione:
L.D. Johnston et al., "Pimozide, like extinction, devalues stimuli associated with sucrose taking", PHARM BIO B, 68(3), 2001, pp. 583-590

Abstract

Conditioned stimuli (CS) can be devalued by exposure to those stimuli in the absence of primary reward. We tested the hypothesis that dopamine (DA) mediates the control of behavior by conditioned appetitive stimuli. Long-Evans rats were trained to respond for sucrose under a heterogeneous chain schedule in which seeking responses (lever press) turned on a houselight [variable interval (VI)-120 s]; taking responses (wheel rum or chain pull) in the presence of the houselight were reinforced [fixed ratio (FR)-1] by a sucrose pellet. When responding on this schedule was stable, the levers were retracted and subjects had access to the sucrose-taking manipulandum only. Sucrose-taking responses were either extinguished or reinforced under the influence of the DA antagonist, pimozide. Control groups were also reinforced for sucrose-taking responses but received no injection or a vehicle injection Frier to each session. Responses of extinction and pimozide-treated groups declined over sessions. Sucrose-seeking responses were measured in a later test when subjects had no access to the sucrose-taking manipulandum or to the reinforcer. Both extinction and pimozide manipulations reduced seeking responses, relative to the respective control groups. Pimozide injectionsin the home cage had no effect. These data support the idea that DA mediates the conditioned reinforcing properties provided by access to the taking link of the chain. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 16/07/20 alle ore 18:33:28