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Titolo:
Reproductive experience modulates dopamine-related behavioral responses
Autore:
Hucke, EETS; Cruz-Casallas, PE; Sider, LH; Felicio, LF;
Indirizzi:
Univ Sao Paulo, Fac Med Vet, Dept Patol, BR-05508970 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-05508970 BC05508970 Sao Paulo, Brazil Univ Los Llanos, Escola Med Vet, Villavicencio, Meta, Colombia Univ Los Llanos Villavicencio Meta Colombia illavicencio, Meta, Colombia
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 68, anno: 2001,
pagine: 575 - 582
SICI:
0091-3057(200103)68:3<575:REMDBR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-AMPHETAMINE; STEREOTYPED BEHAVIOR; BROMOPRIDE TREATMENT; MATERNAL-BEHAVIOR; ESTROGEN PROFILES; NULLIPAROUS WOMEN; NUCLEUS-ACCUMBENS; STEROID-HORMONES; PROLACTIN LEVELS; NEURAL ACTIVITY;
Keywords:
parity; motor activity; hypothermia; stereotypy; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Felicio, LF Univ Sao Paulo, Fac Med Vet, Dept Patol, Av Prof Orlando Marques Paiva 87,Cidade Univ, BR-05508970 Sao Paulo, Brazil Univ Sao Paulo Av Prof Orlando Marques Paiva 87,Cidade Univ Sao Paulo Brazil BR-05508970 BC
Citazione:
E.E.T.S. Hucke et al., "Reproductive experience modulates dopamine-related behavioral responses", PHARM BIO B, 68(3), 2001, pp. 575-582

Abstract

Reproductive experience (RE), i.e., mating, pregnancy, parturition and lactation, has long-term physiological effects. It reduces the basal levels ofcirculating prolactin in parous women, decreases the intensity of nocturnal and diurnal prolactin surges in multigravid rats during early pregnancy, as well as the hormonal and neurochemical responses to the dopamine receptor antagonists metoclopramide and haloperidol. In the present study, we evaluated the possible influences of RE on some dopaminergic-related behaviors:(1) acute responses to a new environment represented by an open-field arena plus injection stress; (2) modulation of behavior after a short-term withdrawal subsequent to 7 days amphetamine (AMPH) pretreatment; (3) stereotypyelicited by AMPH and apomorphine (APO); and (4) APO-induced hypothermia. in the 3-min open-field test, there was a decrease in locomotor activity as a function of RE. Behavioral depression was mild and AMPH pretreatment revealed RE alterations. APO-induced stereotyped behavior was slightly more intense in primiparous animals, although no significant differences were foundin AMPH-induced stereotyped behavior. No differences were observed betweenintact and ovariectomized primiparous and nulliparous animals in APO-induced hypothermia Our data suggest that RE modifies some DA-related behavioralresponses. The physiological relevance of the phenomenon is discussed. (C)2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:21:19