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Titolo:
The effect of (R)-HA966 or ACEA 1021 on dexfenfluramine or (S)-MDMA-induced changes in temperature, activity, and neurotoxicity
Autore:
Russell, BR; Laverty, R;
Indirizzi:
Univ Otago, Sch Med Sci, Dept Pharmacol, Dunedin 9001, New Zealand Univ Otago Dunedin New Zealand 9001 Pharmacol, Dunedin 9001, New Zealand
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 68, anno: 2001,
pagine: 565 - 574
SICI:
0091-3057(200103)68:3<565:TEO(OA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN UPTAKE SITES; RAT-BRAIN; BODY-TEMPERATURE; MDMA ECSTASY; H-3 PAROXETINE; NMDA RECEPTOR; METHYLENEDIOXYMETHAMPHETAMINE MDMA; METHAMPHETAMINE NEUROTOXICITY; SUBSTITUTED AMPHETAMINES; AMBIENT-TEMPERATURES;
Keywords:
ACEA 1021; (R)-HA 966; NMDA antagonists; neurotoxicity; rats; temperature; dexfenfluramine; MDMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Laverty, R Univ Otago, Sch Med Sci, Dept Pharmacol, POB 913, Dunedin 9001,New Zealand Univ Otago POB 913 Dunedin New Zealand 9001 9001, New Zealand
Citazione:
B.R. Russell e R. Laverty, "The effect of (R)-HA966 or ACEA 1021 on dexfenfluramine or (S)-MDMA-induced changes in temperature, activity, and neurotoxicity", PHARM BIO B, 68(3), 2001, pp. 565-574

Abstract

The glycine site-specific N-methyl-D-aspartate (NMDA) antagonist 5-nitro-6,7-dichloro-2,3-quinoxalinedione (ACEA 1021, 4 x 30 mg/ kg, ip) given 30 min before dexfenfluramine (4 x 15 mg/kg, ip, every 2 h) was unable to prevent dexfenfluramine-induced depletion of 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) content, and 5-HT transporter (5-HTT) density. another glycine site-specific NMDA antagonist, R(+)-3-aminohydroxypyrrolidin-2-one [(R)-HA 966] (2 x 30 mg/kg, ip), given 30 min before dexfenfluramine (2 x 10 mg/kg, ip, 2 hourly) was also unable to prevent regional depletion of 5-HT, 5-HIAA, and 5-HTT density. However, ACEA 1021 (4 x 30 mg/kg, ip)given 30 min before (S)-3,4-methylenedioxymethamphetamine (MDMA, 4 x 10 mg/kg, 2 hourly, ip) attenuated the regional depletion of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), 5-HT, 5-HIAA content, and 5-HTT density. ACEA 1021 combined with (S)-MDMA also prevented (S)-MDMA-induced hyperthermiawithout causing hypothermia or preventing an (S)-MDMA- induced increase inlocomotor activity. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:20:06