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Titolo:
Reversal of morphine-induced memory impairment in mice by withdrawal in Morris water maze - Possible involvement of cholinergic system
Autore:
Li, Z; Wu, CF; Pei, G; Xu, NJ;
Indirizzi:
Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110015, Peoples R ChinaShenyang Pharmaceut Univ Shenyang Peoples R China 110015 Peoples R China Chinese Acad Sci, Shanghai Inst Cell Biol, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 68, anno: 2001,
pagine: 507 - 513
SICI:
0091-3057(200103)68:3<507:ROMMII>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS-ALTERNATION PERFORMANCE; OPIOID RECEPTOR AGONISTS; ACETYLCHOLINE-RELEASE; NUCLEUS-ACCUMBENS; WORKING-MEMORY; EXTRACELLULAR ACETYLCHOLINE; OPIATE ANTAGONISTS; PASSIVE-AVOIDANCE; BETA-ENDORPHIN; BRAIN-SLICES;
Keywords:
morphine; memory impairment; naloxone; oxotremorine; physostigmine; Morris water maze;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, CF Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110015, Peoples R China Shenyang Pharmaceut Univ Shenyang Peoples R China 110015 R China
Citazione:
Z. Li et al., "Reversal of morphine-induced memory impairment in mice by withdrawal in Morris water maze - Possible involvement of cholinergic system", PHARM BIO B, 68(3), 2001, pp. 507-513

Abstract

The effects of morphine and morphine withdrawal on memory performance wereexamined in mice by using Morris water maze task. Morphine-induced memory impairment at the doses of 5 and 10 mg/kg recovered after repeated administration Oxotremorine, a muscarinic receptor agonist, at the dose of 0.1 mg/kg ip, and physostigmine, a cholinesterase inhibitor, at the dose of 0.1 mg/kg ip, significantly antagonized morphine (10 mg/kg sc)-induced memory impairment in mice. Furthermore, repeated naloxone (0.5 mg/kg ip) attenuated scopolamiue (0.2 mg/kg ip)-induced memory impairment. By using escalating doses of morphine for 13 days, morphine-induced memory impairment was continuously maintained. When withdrawal was precipitated by naloxone (5 mg/kg ip),or administration of oxotremorine (0.1 and 0.2 mg/kg ip) or physostigmine (0.05 and 0.1 mg/kg ip), the impairment was completely reversed. These results suggest that morphine-induced memory impairment could he partially due to the inhibition of the central cholinergic activity. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 08/04/20 alle ore 08:52:00