Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Facilitation of latent inhibition by the atypical antipsychotic risperidone
Autore:
Alves, CRR; Silva, MTA;
Indirizzi:
Univ Sao Paulo, Inst Psychol, Dept Expt Psychol, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-05508900 BC05508900 Sao Paulo, Brazil
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 68, anno: 2001,
pagine: 503 - 506
SICI:
0091-3057(200103)68:3<503:FOLIBT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPHETAMINE-INDUCED DISRUPTION; SWITCHING MODEL; HALOPERIDOL; CLOZAPINE; RATS; DRUGS; ANTAGONISM; POTENTIATION; ENHANCEMENT; ATTENTION;
Keywords:
risperidone; latent inhibition; LI; schizophrenia; animal models; atypical antipsychotics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Silva, MTA Univ Sao Paulo, Inst Psychol, Dept Expt Psychol, Ave Prof MelloMoraes 1721, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo Ave Prof Mello Moraes 1721 Sao Paulo Brazil BR-05508900 BC
Citazione:
C.R.R. Alves e M.T.A. Silva, "Facilitation of latent inhibition by the atypical antipsychotic risperidone", PHARM BIO B, 68(3), 2001, pp. 503-506

Abstract

The action of the atypical antipsychotic risperidone on latent inhibition (LI), an animal model of schizophrenia, was investigated. The parameters ofthe procedure were set at values insufficient to generate LI in control rats. On the first day, rats administered 0.5, 1.0, or 2.0 mg/kg ip risperidone or vehicle were preexposed (PE) to 10 tone presentations. On the second day, they were again injected with drug or vehicle and then submitted to two conditioned stimulus (CS; tone)-unconditioned stimulus (US; shock) pairings. On the third day, suppression of their drinking response under the CS was measured. Nonpreexposed (NPE) animals were submitted to the same procedure except for the tone preexposure. On the suppression test, LI was not observed in control rats as well as in animals given 0.5 mg/kg risperidone. Animals given 1.0 and 2.0 mg risperidone, however, displayed an LI effect. The facilitation of LI by risperidone gives additional support to the LI paradigm as an animal model of schizophrenia. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:46:31