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Titolo:
Increased sensitivity of dopamine systems following reproductive experience in rats
Autore:
Byrnes, EM; Byrnes, JJ; Bridges, RS;
Indirizzi:
Tufts Univ, Sch Vet Med, Dept Biomed Sci, N Grafton, MA 01536 USA Tufts Univ N Grafton MA USA 01536 ept Biomed Sci, N Grafton, MA 01536 USA New England Med Ctr, Dept Psychiat, Boston, MA 02111 USA New England Med Ctr Boston MA USA 02111 pt Psychiat, Boston, MA 02111 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 68, anno: 2001,
pagine: 481 - 489
SICI:
0091-3057(200103)68:3<481:ISODSF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRIATAL DOPAMINE; POSTPARTUM PSYCHOSIS; PUERPERAL PSYCHOSIS; ESTROUS-CYCLE; MENSTRUAL-CYCLE; SEX-DIFFERENCES; ANIMAL-MODEL; FEMALE RATS; ESTRADIOL; SCHIZOPHRENIA;
Keywords:
parity; dopamine; postpartum psychosis; PPI; oral stereotypy; prolactin; apomorphine; estrogen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Byrnes, EM Tufts Univ, Sch Vet Med, Dept Biomed Sci, 200 Westboro Rd, N Grafton, MA 01536 USA Tufts Univ 200 Westboro Rd N Grafton MA USA 01536 MA 01536 USA
Citazione:
E.M. Byrnes et al., "Increased sensitivity of dopamine systems following reproductive experience in rats", PHARM BIO B, 68(3), 2001, pp. 481-489

Abstract

Several studies have suggested that alterations in forebrain dopamine activity during the postpartum period may result in the onset of postpartum psychosis in women [J. Psychosom. Obstet. Gynecol. 19 (1998) 104; Prog. Neuro-Psychopharmacol. Biol. Psychiatry 17 (1993) 571; J. Clin. Psychiatry 51 (1990) 365.]. The present study investigated whether increased dopamine activity in these forebrain regions is a normal consequence of reproductive experience in rodents. Both intact and ovariectomized parous and nulliparous females were tested for their responses to the dopamine agonist apomorphine using two behavioral measures, prepulse inhibition (PPI) and oral stereotypy. In addition, dopamine and DOPAC levels were measured in tissue from the striatum and nucleus accumbens together with circulating plasma prolactin levels. The results of the behavioral studies demonstrate an increased response to apomorphine in parous females. Parous subjects also hail increased levels of dopamine and DOPAC hi striatal tissue and lower levels of circulating prolactin. Ovariectomy in nulliparous females resulted in a potentiated response to apomorphine with regard to the disruption of PPI, as well as a significant decrease in the plasma prolactin levels, as compared with intactnulliparous females. These data suggest that increased dopamine activity in forebrain regions occurs as a consequence of parity, which persists for aminimum of several weeks postpartum. These findings support the hypothesisthat increased dopamine sensitivity in forebrain dopamine regions may be one potential mechanism underlying the development of postpartum psychosis in women. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:06:23