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Titolo:
Testing and analytical procedures for laboratory studies involving nonresponders during a limited observation period - An illustration using male sexual behavior in rats
Autore:
Rowland, DL; Thornton, JA;
Indirizzi:
Valparaiso Univ, Dept Psychol, Valparaiso, IN 46383 USA Valparaiso Univ Valparaiso IN USA 46383 Psychol, Valparaiso, IN 46383 USA Eastern Michigan Univ, Ypsilanti, MI 48197 USA Eastern Michigan Univ Ypsilanti MI USA 48197 niv, Ypsilanti, MI 48197 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 68, anno: 2001,
pagine: 403 - 409
SICI:
0091-3057(200103)68:3<403:TAAPFL>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTOSTERONE LEVELS; WISTAR RATS; 8-OH-DPAT; LESIONS; NUCLEUS; MOTIVATION; EXPERIENCE; RECEPTORS; REGIONS; FEMALE;
Keywords:
male sexual behavior; ejaculation; intromission; rat; survival analysis; survival regression analysis; hazard function; 8-OH-DPAT; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Rowland, DL Valparaiso Univ, Dept Psychol, Valparaiso, IN 46383 USA Valparaiso Univ Valparaiso IN USA 46383 paraiso, IN 46383 USA
Citazione:
D.L. Rowland e J.A. Thornton, "Testing and analytical procedures for laboratory studies involving nonresponders during a limited observation period - An illustration using male sexual behavior in rats", PHARM BIO B, 68(3), 2001, pp. 403-409

Abstract

In many laboratory studies, a subpopulation of subjects fails to exhibit the response under investigation during the period of observation. For example, within any population of male rats, there is significant variation in the expression of sexual behavior in the presence of a receptive female. Some males may never display the full sequence of behaviors leading to ejaculation within the typical time frame of the testing session, with the resulting lack of behavioral response presenting problems in the analysis of the data. Conventional strategies range from screening such males from the studyor dropping them from the analysis to constructing new variables based on estimates from existing parameters or increasing the length of the test session to capture sexual responses in a greater portion of males. Herein, we present an alternative strategy for analyzing data where outcomes are absent due to the limited observation period. Survival regression analysis enables inclusion of all subjects in the analysis whether or not they have shownthe behavior of interest. Use of such a strategy not only has potential toreveal new results but also guards against bias from excluding nonresponders from the study or dropping more males from one experimental condition than another. Furthermore, this procedure can be helpful in generating the conditional probability (increase, decrease, or constant) of the response with the passage of time based on the hazard function and in estimating parameters for establishing an optimal behavioral test length for future studies. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:53:26