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Titolo:
Genetic variants of the serotonin system and weight change during clozapine treatment
Autore:
Hong, CJ; Lin, CH; Yu, YWY; Yang, KH; Tsai, SJ;
Indirizzi:
Vet Gen Hosp Taipei, Dept Psychiat, Taipei 11217, Taiwan Vet Gen Hosp Taipei Taipei Taiwan 11217 t Psychiat, Taipei 11217, Taiwan Natl Yang Ming Univ, Sch Med, Div Psychiat, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 , Div Psychiat, Taipei 112, Taiwan Kai Suan Psychiat Hosp, Kaohsiung, Taiwan Kai Suan Psychiat Hosp Kaohsiung Taiwan sychiat Hosp, Kaohsiung, Taiwan
Titolo Testata:
PHARMACOGENETICS
fascicolo: 3, volume: 11, anno: 2001,
pagine: 265 - 268
SICI:
0960-314X(200104)11:3<265:GVOTSS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLELIC VARIATION; BODY-WEIGHT; FOOD-INTAKE; ASSOCIATION; RECEPTOR; SCHIZOPHRENIA; GAIN; POLYMORPHISM; DRUGS; RATS;
Keywords:
clozapine; genotype; schizophrenia; serotonin receptor; serotonin transporter; weight change;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Tsai, SJ Vet Gen Hosp Taipei, Dept Psychiat, 201,Shih Pai Rd,Sec 2, Taipei11217, Taiwan Vet Gen Hosp Taipei 201,Shih Pai Rd,Sec 2 Taipei Taiwan 11217 an
Citazione:
C.J. Hong et al., "Genetic variants of the serotonin system and weight change during clozapine treatment", PHARMACOGEN, 11(3), 2001, pp. 265-268

Abstract

Clozapine-induced weight gain may impair health and affect patient compliance. The aim of this study is to investigate the relationship between the genetic variants of the serotonin system and clozapine-induced body weight change (BWC). Ninety-three treatment-resistant schizophrenic patients were weighed monthly for 4 months during clozapine treatment, At the conclusion of treatment, patients had gained an average of 2.4 kg body weight, with BWCranging from -17.5 to +12.9 kg. The levels of the serotonin transporter variants, serotonin 2A serotonin 2C and serotonin 6, demonstrated no statistically significant relationship to BWC. Patients with a lower initial body mass index demonstrated a greater weight gain associated with clozapine treatment. Further exploration of the neurotransmitters implicated in the antipsychotic-induced BWC is important in order to reduce the morbidity and noncompliance associated with weight gain, Pharmacogenetics 11:265-268 (C) 2001Lippincott Williams & Wilkins.

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Documento generato il 08/04/20 alle ore 23:45:17