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Titolo:
The case for gastrin-releasing peptide acting as a morphogen when it and its receptor are aberrantly expressed in cancer
Autore:
Jensen, JAG; Carroll, RE; Benya, RV;
Indirizzi:
Univ Florida, Hlth Sci Ctr, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Sci Ctr, Gainesville, FL 32610 USA Univ Illinois, Dept Med, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 inois, Dept Med, Chicago, IL 60612 USA Chicago Vet Adm Med Ctr, W Side Div, Chicago, IL 60612 USA Chicago Vet AdmMed Ctr Chicago IL USA 60612 e Div, Chicago, IL 60612 USA
Titolo Testata:
PEPTIDES
fascicolo: 4, volume: 22, anno: 2001,
pagine: 689 - 699
SICI:
0196-9781(200104)22:4<689:TCFGPA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL LUNG-CANCER; HUMAN BREAST-CANCER; HUMAN COLON-CANCER; SOMATOSTATIN ANALOG RC-160; HORMONE ANTAGONIST CETRORELIX; VASOACTIVE-INTESTINAL-PEPTIDE; BOMBESIN-RELATED PEPTIDES; HEPATOCYTE GROWTH-FACTOR; HIGH-AFFINITY RECEPTORS; SWISS 3T3 CELLS;
Keywords:
FAK, focal adhesion kinase; GI, gastrointestinal; GRP, gastrin-releasing peptide; GRP-R, GRP receptor; SCCL, small cell cancer of the lung;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Benya, RV Univ Florida, Hlth Sci Ctr, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Gainesville, FL 32610 USA
Citazione:
J.A.G. Jensen et al., "The case for gastrin-releasing peptide acting as a morphogen when it and its receptor are aberrantly expressed in cancer", PEPTIDES, 22(4), 2001, pp. 689-699

Abstract

Gastrin-releasing peptide (GRP) and its receptor (CRP-R) are frequently expressed by cancers of the gastrointestinal tract, breast, lung, and prostate. Most studies have found that GRP and its amphibian homologue bombesin act to increase tumor cell proliferation, leading to the hypothesis that thispeptide hormone is a mitogen important for the growth of various cancers. Yet GRP/GRP-R co-expression in cancer promotes the development of. a well-differentiated phenotype: while multiple studies suggest that the presence of these 2 proteins confer a survival advantage. Along with recent reports showing that GRP and its receptor critically regulate aspects of colon and lung organogenesis, we argue that these proteins do not function primarily as mitogens when aberrantly expressed in cancer. Rather, we postulate that GRP/GRP-R are once-fetal antigens that function as morphogens, with their effect on tumor cell proliferation being a component property of their ability to regulate differentiation. Thus aberrant GRP/GRP-R expression in cancerrecapitulates, albeit in a dysfunctional manner, their normal role in development. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:39:25