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Titolo:
Do antiepileptic drugs differ in suppressing interictal epileptiform activity in children?
Autore:
Libenson, MH; Caravale, B;
Indirizzi:
Floating Hosp Children, New England Med Ctr, Div Pediat Neurol, Dept Pediat, Boston, MA 02111 USA Floating Hosp Children Boston MA USA 02111 t Pediat, Boston, MA 02111 USA Floating Hosp Children, New England Med Ctr, Div Pediat Neurol, Dept Neurol, Boston, MA 02111 USA Floating Hosp Children Boston MA USA 02111 t Neurol, Boston, MA 02111 USA Tufts Univ, Sch Med, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111Tufts Univ, Sch Med, Boston, MA 02111 USA
Titolo Testata:
PEDIATRIC NEUROLOGY
fascicolo: 3, volume: 24, anno: 2001,
pagine: 214 - 218
SICI:
0887-8994(200103)24:3<214:DADDIS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; CARBAMAZEPINE; EPILEPSY; ELECTROENCEPHALOGRAM; VALPROATE; SODIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Libenson, MH Floating Hosp Children, New England Med Ctr, Div Pediat Neurol, Dept Pediat, 330,750 Washington St, Boston, MA 02111 USA Floating Hosp Children 330,750 Washington St Boston MA USA 02111
Citazione:
M.H. Libenson e B. Caravale, "Do antiepileptic drugs differ in suppressing interictal epileptiform activity in children?", PED NEUROL, 24(3), 2001, pp. 214-218

Abstract

Antiepileptic drugs may suppress interictal epileptiform activity in addition to suppressing seizures, although the comparative rates of suppression of interictal epileptiform activity for phenobarbital (PHB), carbamazepine (CBZ), and valproate (VPA) in children are unknown. Electroencephalogram (EEG) pairs were identified in which the first tracing illustrated interictalepileptiform activity before antiepileptic drug treatment; the rate of clearance of such activity in the subsequent tracing was assessed according tothe drug introduced. EEG pairs (n = 213) were identified for CBZ, PHB, andVPA. Overall suppression rates of epileptiform activity in the second EEG were 12/55 (22%) for PHB, 27/81 (33%) for CBZ, and 35/77 (46%) for VPA (P =0.005 for VPA vs PHB). When suppression rates were assessed comparing sleep-state pairs, suppression rates were 24/80 (30%) for PHB, 51/129 (40%) forCBZ, and 60/120 (50%) for VPA (P = 0.005 for PHB vs VPA). A subanalysis for focal discharges yielded suppression rates of 10/43 (23%) for PHB, 19/60 (32%) for CBZ, and 8/19 (42%) for VPA; for generalized discharges, 2/12 (17%) for PHB, 8/21 (38%) for CBZ, and 27/58 (47%) for VPA. VPA, and to a lesser extent CBZ, appeared superior to PHB in suppressing interictal epileptiform activity, including both focal and generalized epileptiform activity. (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:33:18