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Titolo:
Involvement of lipid peroxidation in spontaneous pancreatitis in WBN/Kob rats
Autore:
Furukawa, F; Nishikawa, A; Kasahara, K; Miyauchi, M; Nakamura, H; Son, HY; Uchida, K; Hirose, M;
Indirizzi:
Natl Inst Hlth Sci, Div Pathol, Setagaya Ku, Tokyo 1588501, Japan Natl Inst Hlth Sci Tokyo Japan 1588501 Setagaya Ku, Tokyo 1588501, Japan Nagoya Univ, Sch Agr, Lab Food & Biodynam, Nagoya, Aichi 464, Japan NagoyaUniv Nagoya Aichi Japan 464 d & Biodynam, Nagoya, Aichi 464, Japan
Titolo Testata:
PANCREAS
fascicolo: 4, volume: 22, anno: 2001,
pagine: 427 - 430
SICI:
0885-3177(200105)22:4<427:IOLPIS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCTION;
Keywords:
WBN/Kob rat; pancreatitis; lipid peroxidation; 4-hydroxy-2-nonenal; 4-hydroxy-2-hexenal; malondialdehyde;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Furukawa, F Natl Inst Hlth Sci, Div Pathol, Setagaya Ku, 1-18-1 Kamiyoga, Tokyo 1588501, Japan Natl Inst Hlth Sci 1-18-1 Kamiyoga Tokyo Japan 1588501 Japan
Citazione:
F. Furukawa et al., "Involvement of lipid peroxidation in spontaneous pancreatitis in WBN/Kob rats", PANCREAS, 22(4), 2001, pp. 427-430

Abstract

To cast light on the mechanisms underlying development of spontaneous pancreatitis lesions, tissues from WBN/Kob rats at various ages were histopathologically and immunohistochemically investigated with special reference to the existence of the lipid peroxidation products 4-hydroxy-2-nonenal (HNE),4-hydroxy-2-hexenal (HHE, and malondialdehyde (MDA). Male 4-20-week-old WBN/Kob rats were killed to allow sampling of pancreatic tissues, which were fixed in cold acetone and 10% neutral-buffered formalin, and then processedfor routine histopathology as well as immunohistochemistry for proteins modified by HNE, HHE, and MDA. Although no remarkable histologic changes werenoted in younger animals, edema, hemorrhage, inflammatory cell infiltration, fibrosis, vacuolation of acinar cells, and ductular proliferation were observed in exocrine pancreatic tissue from animals at 10-15 weeks of age. In animals aged 20 weeks, the lesions had progressed remarkably and depositsof hemosiderin were apparent with fibrosis. Immunohistochemical examination for lipid peroxidation product-modified proteins showed HNE and MDA to benegative in all pancreatic tissues, but HHE was positive in the areas involving atrophy of acinar cells and fibrosis in the islets. The results of the present study thus provide support for the conclusion that lipid peroxidation during spontaneous pancreatitis in WBN/Kob rats may possibly be involved in the development of diabetes in this model.

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Documento generato il 19/09/20 alle ore 18:11:55