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Titolo:
Ascites of rat experimental model of severe acute pancreatitis induces lung injury
Autore:
Fujita, M; Masamune, A; Satoh, A; Sakai, Y; Satoh, K; Shimosegawa, T;
Indirizzi:
Tohoku Univ, Sch Med, Dept Gastroenterol, Div Internal Med,Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan
Titolo Testata:
PANCREAS
fascicolo: 4, volume: 22, anno: 2001,
pagine: 409 - 418
SICI:
0885-3177(200105)22:4<409:AOREMO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; FACTOR-KAPPA-B; RESPIRATORY-DISTRESS-SYNDROME; ACUTE HEMORRHAGIC-PANCREATITIS; CERULEIN-INDUCED PANCREATITIS; SYSTEMIC COMPLICATIONS; INFLAMMATORY CYTOKINES; FLUID; ACTIVATION; INTERLEUKIN-6;
Keywords:
acute pancreatitis; ascitic fluids; lung injury; cytokines; nuclear factor kappa B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Masamune, A Tohoku Univ, Sch Med, Dept Gastroenterol, Div Internal Med,Aoba Ku, SeiryoMachi, Sendai, Miyagi 9808574, Japan Tohoku Univ Seiryo Machi Sendai Miyagi Japan 9808574 74, Japan
Citazione:
M. Fujita et al., "Ascites of rat experimental model of severe acute pancreatitis induces lung injury", PANCREAS, 22(4), 2001, pp. 409-418

Abstract

The molecular mechanisms that lead from acute pancreatitis (AP) to multiple organ failure remain to be clarified. We previously reported that asciticfluids from a rat model of severe acute pancreatitis (pancreatitis-associated ascitic fluids, PAAF) transcriptionally activated endothelial cells andleukocytes in vitro. To clarify the role of ascitic fluids on the development of multiple organ failure in AP, we examined the effects of PAAF on theprognosis and immunohistologic findings in cerulein pancreatitis, an experimental model of mild pancreatitis in vivo. Intraperitoneal injection of PAAF decreased the survival rates in a dose-dependent manner. Histologically,destruction of vessels, alveolar septal thickening, interstitial hypertrophy, and infiltration of inflammatory cells were prominent in the lung of PAAF-injected rats. Transcription factor, nuclear factor kappaB (NF-kappaB) was activated and the mRNA levels of tumor necrosis factor-alpha and interleukin-lp were increased in the lung of the PAAF-injected rats. The permeability index assessed by Evans blue assay and the lung myeloperoxidase activity levels were significantly higher in the PAAF-injected rats than in controls. Inhibition of NF-kappaB ameliorated the histologic findings and improved the survival rates. Our results suggest that PAAF play a role in the pathogenesis of lung injury in severe AP, at least in part through the activation of NF-kappaB.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:04:39