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Titolo:
Evidence-based data from animal and human experimental studies on pain relief with antidepressants: A structured review
Autore:
Fishbain, DA; Cutler, R; Rosomoff, HL; Rosomoff, RS;
Indirizzi:
Univ Miami, Comprehens Pain & Rehabil Ctr, Miami Beach, FL 33139 USA Univ Miami Miami Beach FL USA 33139 ehabil Ctr, Miami Beach, FL 33139 USA Univ Miami, Sch Med, Dept Psychiat, Miami Beach, FL 33139 USA Univ Miami Miami Beach FL USA 33139 t Psychiat, Miami Beach, FL 33139 USA Univ Miami, Sch Med, Dept Neurol Surg, Miami Beach, FL 33139 USA Univ Miami Miami Beach FL USA 33139 eurol Surg, Miami Beach, FL 33139 USA Univ Miami, Sch Med, Dept Anesthesiol, Miami Beach, FL 33139 USA Univ Miami Miami Beach FL USA 33139 nesthesiol, Miami Beach, FL 33139 USA
Titolo Testata:
PAIN MEDICINE
fascicolo: 4, volume: 1, anno: 2000,
pagine: 310 - 316
SICI:
1526-2375(200012)1:4<310:EDFAAH>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETIC NEUROPATHY SYMPTOMS; LOW-BACK-PAIN; TRICYCLIC ANTIDEPRESSANTS; POSTHERPETIC NEURALGIA; ANTI-DEPRESSANTS; DOUBLE-BLIND; RATS; AMITRIPTYLINE; DESIPRAMINE; MORPHINE;
Keywords:
structured review; antidepressants; antinociception; chronic pain; serotonergic; serotonergic/noradrenergic; antinociceptive effect; animal pain models;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Fishbain, DA Univ Miami, Comprehens Pain & Rehabil Ctr, 600 Alton Rd, Miami Beach, FL 33139 USA Univ Miami 600 Alton Rd Miami Beach FL USA 33139 FL 33139 USA
Citazione:
D.A. Fishbain et al., "Evidence-based data from animal and human experimental studies on pain relief with antidepressants: A structured review", PAIN MED, 1(4), 2000, pp. 310-316

Abstract

Objective. It has been hypothesized that serotonin reuptake inhibitor antidepressants (ADs) are only weakly antinociceptive but augment noradrenergic(NA) antinociception. Thus, ADs with combined serotonergic (SN) and NA activity, (i.e., the serotonergic/noradrenergic (SN/NA) ADs) should have greater antinociceptive activity versus the NA ADs, which in turn should have more antinociceptive activity than the SN ADs. The objective of this structured review was to test this hypothesis by reviewing relevant basic science literature on the treatment of experimental pain with the above different types of ADs. Design, Setting, Participants, Outcome, Measures. Animal or human experimental AD pain treatment studies were located by the usual search methods. For animal studies only placebo-controlled studies were included for review. For human studies only double blind placebo-controlled studies were selected for review. The animal and human studies were then sorted according to the pain model represented, e.g., neuropathic pain model. Studies were then characterized according to the type of AD utilized, and the antinociceptive outcome of the AD trial. Results. Twenty-two animal studies and 5 human studies fulfilled the inclusion criteria of this structured review. Within the animal nonspecific painmodel there were 10 SN/NA AD trials, 9 NA AD trials and 7 SN AD trials. Ofthese trials 100%, 88.9%, and 14.3% respectfully demonstrated a positive AD antinociceptive effect. Overall, for all the animal models there were 25 SN/NA, 9 NA,and 8 SN trials. Of these trials 92%, 88.9%, and 25% respectfully demonstrated a positive AD antinociceptive effect. For the human pain models, only the SN/NA ADs had been utilized in 7 trials. Here in 42.8% of the trials there was a reported antinociceptive effect. Conclusions. Overall, the results of this structured review support the above hypothesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 07:34:12