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Titolo:
Whole-body kinetics and dosimetry of cis-4-[F-18]fluoro-L-proline
Autore:
Borner, AR; Langen, KJ; Herzog, H; Hamacher, K; Muller-Mattheis, V; Schmitz, T; Ackermann, R; Coenen, HH;
Indirizzi:
Res Ctr Julich, Inst Med, D-52425 Julich, Germany Res Ctr Julich Julich Germany D-52425 Inst Med, D-52425 Julich, Germany Univ Dusseldorf, Clin Nucl Med, D-4000 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-4000 ed, D-4000 Dusseldorf, Germany Res Ctr Julich, Inst Nucl Chem, Julich, Germany Res Ctr Julich Julich Germany r Julich, Inst Nucl Chem, Julich, Germany Univ Dusseldorf, Urol Klin, D-4000 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-4000 in, D-4000 Dusseldorf, Germany
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 3, volume: 28, anno: 2001,
pagine: 287 - 292
SICI:
0969-8051(200104)28:3<287:WKADOC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-TUMORS; PROTEIN-SYNTHESIS; TYROSINE; SPECT; PET; O-(2-FLUOROETHYL)-L-TYROSINE; SOFTWARE; ACID;
Keywords:
cis-4-[F-18]fluoro-L-proline (cis-FPro); dosimetry; whole-body distribution; amino acids; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Langen, KJ Res Ctr Julich, Inst Med, POB 1913, D-52425 Julich, Germany ResCtr Julich POB 1913 Julich Germany D-52425 Julich, Germany
Citazione:
A.R. Borner et al., "Whole-body kinetics and dosimetry of cis-4-[F-18]fluoro-L-proline", NUCL MED BI, 28(3), 2001, pp. 287-292

Abstract

The whole-body distribution of 4-cis[F-18]fluoro-L-proline (cis-FPro) was studied in six patients with urological tumors by PET. Based on the IMEDOSEand MIRDOSE procedures radiation absorbed doses were estimated from whole-body PET scans acquired at 1 and 3-5 h after i.v. injection of 400 MBq cis-FPro. Cis-FPro showed high retention in the renal cortex and a slight uptake in liver and pancreas. Urinary excretion ranged from 12 to 19% at 5 h p.i. Highest absorbed doses were found for the urinary bladder wall and the kidneys (44.1/44.0 mu Gy/MBq). The effective dose according to ICRP 60 was 15.1 mu Sv/MBq for adults. This leads to an effective dose of 6.0 mSv in a PET study using 400 MBq cis-FPro. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 18:21:19