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Titolo:
Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production
Autore:
Genc, S; Kuralay, F; Genc, K; Akhisaroglu, M; Fadiloglu, S; Yorukoglu, K; Fadiloglu, M; Gure, A;
Indirizzi:
Dokuz Eylul Univ, Sch Med, Dept Med Biol, TR-35340 Izmir, Turkey Dokuz Eylul Univ Izmir Turkey TR-35340 Med Biol, TR-35340 Izmir, Turkey Dokuz Eylul Univ, Sch Med, Dept Biochem, TR-35340 Izmir, Turkey Dokuz Eylul Univ Izmir Turkey TR-35340 t Biochem, TR-35340 Izmir, Turkey Dokuz Eylul Univ, Sch Med, Dept Physiol, TR-35340 Izmir, Turkey Dokuz Eylul Univ Izmir Turkey TR-35340 t Physiol, TR-35340 Izmir, Turkey Dokuz Eylul Univ, Sch Med, Dept Neurol, TR-35340 Izmir, Turkey Dokuz EylulUniv Izmir Turkey TR-35340 pt Neurol, TR-35340 Izmir, Turkey Dokuz Eylul Univ, Sch Med, Dept Pathol, TR-35340 Izmir, Turkey Dokuz EylulUniv Izmir Turkey TR-35340 pt Pathol, TR-35340 Izmir, Turkey
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 298, anno: 2001,
pagine: 139 - 141
SICI:
0304-3940(20010202)298:2<139:EENI1>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED RAT ASTROCYTES; BIOLOGICAL-FLUIDS; IN-VIVO; NITRATE; BRAIN;
Keywords:
erythropoietin; experimental Parkinsonism; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neuroprotection; nitric oxide; C57/BL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Genc, S Dokuz Eylul Univ, Sch Med, Dept Med Biol, TR-35340 Izmir, Turkey Dokuz Eylul Univ Izmir Turkey TR-35340 l, TR-35340 Izmir, Turkey
Citazione:
S. Genc et al., "Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production", NEUROSCI L, 298(2), 2001, pp. 139-141

Abstract

Erythropoietin (EPO), produced by the kidney and fetal liver, is a cytokine-hormone that stimulates erythropoiesis under hypoxic conditions. It has been shown that EPO is produced in the central nervous system and its receptor is expressed on neurons. Since EPO has neuroprotective effects in vitro and in vivo against brain injury, we investigated the effect of EPO treatment on locomotor activities of animals, survival of nigral dopaminergic neurons and nitrate levels in substantia nigra and striatum in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal model of Parkinsonism inC57/BL mice. Our findings suggest that EPO has protective and treating effect in MPTP-induced neurotoxicity in this mouse model of Parkinson's Disease via increasing nitric oxide production. (C) 2001 Elsevier Science IrelandLtd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 18:02:13