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Titolo:
Genotypes of catechol-O-methyltransferase and response to levodopa treatment in patients with Parkinson's disease
Autore:
Lee, MS; Lyoo, CH; Ulmanen, I; Syvanen, AC; Rinne, JO;
Indirizzi:
Dept Neurol, FIN-20521 Turku, Finland Dept Neurol Turku Finland FIN-20521 ept Neurol, FIN-20521 Turku, Finland Yonsei Univ, Coll Med, Yongdong Severance Hosp, Dept Neurol, Seoul 120749,South Korea Yonsei Univ Seoul South Korea 120749 pt Neurol, Seoul 120749,South Korea Natl Publ Hlth Inst, Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland Publ Hlth Inst, Helsinki, Finland Univ Uppsala, Dept Med Sci, S-75105 Uppsala, Sweden Univ Uppsala UppsalaSweden S-75105 ept Med Sci, S-75105 Uppsala, Sweden Turku PET Ctr, FIN-20521 Turku, Finland Turku PET Ctr Turku Finland FIN-20521 PET Ctr, FIN-20521 Turku, Finland
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 298, anno: 2001,
pagine: 131 - 134
SICI:
0304-3940(20010202)298:2<131:GOCART>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMORPHISM; COMT; GENE; ASSOCIATION; DIFFERENCE; TOLCAPONE; ALLELE;
Keywords:
catechol-O-methyltransferase; levodopa test; minisequencing; multiple system atrophy; Parkinson's disease; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Rinne, JO Dept Neurol, POB 52, FIN-20521 Turku, Finland Dept Neurol POB 52Turku Finland FIN-20521 20521 Turku, Finland
Citazione:
M.S. Lee et al., "Genotypes of catechol-O-methyltransferase and response to levodopa treatment in patients with Parkinson's disease", NEUROSCI L, 298(2), 2001, pp. 131-134

Abstract

A single nucleotide polymorphism at the nucleotide 1947 in the catechol-O-methyltransferase (COMT) gene encodes the high and low activity forms of the enzyme. We investigated COMT genotypes of 73 Korean patients with Parkinson's disease (PD), 29 with multiple system atrophy (MSA), and 49 controls, and analyzed the response to levodopa challenge in the PD patients. We found no significant difference in the distribution of the COMT genotypes amongthe three groups. The frequencies of the G- and A-alleles in the total population were 75 and 25%, respectively. The levodopa response was determinedby a single oral levodopa challenge test with Sinemet* (25/250 mg) in the patients with PD. The motor response evaluated by the time to peak response, the duration and magnitude of the response in the motor part of the Unified Parkinson's Disease Rating Scale; tapping or walking times showed no significant difference between the genotypes, Thus, pharmacokinetic or pharmacodynamic factors other than the investigated genetic variant of the COMT enzyme seem to determine the response to levodopa in PD. (C) 2001 Elsevier Science Ireland Ltd. Ail rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:29:07