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Titolo:
Involvement of central histaminergic neurons in polypnea induced by hyperthermia in rabbits
Autore:
Iwase, M; Izumizaki, M; Kanamaru, M; Homma, I;
Indirizzi:
Showa Univ, Sch Med, Dept Physiol, Shinagawa Ku, Tokyo 1428555, Japan Showa Univ Tokyo Japan 1428555 ysiol, Shinagawa Ku, Tokyo 1428555, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 298, anno: 2001,
pagine: 119 - 122
SICI:
0304-3940(20010202)298:2<119:IOCHNI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPERATURE-INDUCED POLYPNEA; TRACHEAL TENSION; RAT-BRAIN; MICE; NERVE;
Keywords:
polypnea; hyperthermia; histamine h1 receptors; pyrilamine; S(+)alpha; -fluoromethylhistidine; preoptic area; anterior hypothalamus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Iwase, M Showa Univ, Sch Med, Dept Physiol, Shinagawa Ku, 1-5-8 Hatanodai,Tokyo 1428555, Japan Showa Univ 1-5-8 Hatanodai Tokyo Japan 1428555 yo 1428555, Japan
Citazione:
M. Iwase et al., "Involvement of central histaminergic neurons in polypnea induced by hyperthermia in rabbits", NEUROSCI L, 298(2), 2001, pp. 119-122

Abstract

A role of central histamine in the preoptic area/anterior hypothalamus (POA/AH) for the regulation of hyperthermia-induced polypnea was examined in anesthetized, paralyzed, vagotomized and artificially ventilated rabbits. Phrenic nerve activities were recorded to monitor respiratory neuronal output. Hyperthermia increased respiratory frequency by reductions of inspiratorytime (T-1) and expiratory time (T-E) Pyrilamine, an H1 receptor antagonist, which was applied to the POA/AH reduced polypnea under hyperthermia. The effect of S(+)alpha -fluoromethylhistidine, a specific inhibitor of histidine decarboxylase, applied in a lateral ventricle was comparable to the effect of pyrilamine on polypnea. Moreover, histamine dihydrochloride applied into the POA/AH at a normal body temperature produced polypnea by reductionsof T-1 and T-E The results suggest that central histamine in the POA/AH contributes to the generation of poiypnea in hyperthermia through H1 receptors. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:50:18