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Titolo:
Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from PA(1-42) insult
Autore:
Kim, DSHL; Park, SY; Kim, JY;
Indirizzi:
Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago,IL 60612 USA Univ Illinois Chicago IL USA 60612 s Pharmaceut Sci, Chicago,IL 60612 USA Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 & Pharmacognosy, Chicago, IL 60612 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 303, anno: 2001,
pagine: 57 - 61
SICI:
0304-3940(20010427)303:1<57:CFCLL(>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMER-DISEASE; GINKGO-BILOBA; BETA;
Keywords:
natural antioxidant; turmeric; curcuminoid; Alzheimer disease; beta; A(1-42); PC12 cells; HUVEC cells; protection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, DSHL Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, 833 S Wood St, Chicago, IL 60612 USA Univ Illinois 833 S Wood St Chicago IL USA 60612 o, IL 60612 USA
Citazione:
D.S.H.L. Kim et al., "Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from PA(1-42) insult", NEUROSCI L, 303(1), 2001, pp. 57-61

Abstract

beta -Amyloid (PA) induced oxidative stress is a well-established pathway of neuronal cell death in Alzheimer's disease. From turmeric, Curcuma longaL. (Zingiberaceae), three curcuminoids, curcumin, demethoxycurcumin, and bisdemethoxycurcumin, were found to protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial (HUVEC) cells from betaA(1-42) insult, as measured by 3-[4,5-dimethylthiazol-2-yl]-2,5-dipheny bromide reductionassay. ED50 values of curcumin, demethoxycurcumin, and bisdemethoxycurcumin toward PC12 and HUVEC cells were 7.1 +/- 0.3, 4.7 +/- 0.1, 3.5 +/- 0.2 mug/ml and 6.8 +/- 0.4, 4.2 +/- 0.3, and 3.0 +/- 0.3 mug/ml, respectively. These compounds were better antioxidants than alpha -tocopherol as determinedby DPPH radical trapping experiment. alpha -Tocopherol did not protect thecells from betaA(1-42) insult even at > 50 mug/ml concentration. The results suggest that these compounds may be protecting the cells from betaA(1-42) insult through antioxidant pathway. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:19:00