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Titolo:
D-3 dopamine receptors in rat spinal cord: implications for sensory and motor function
Autore:
Levant, B; McCarson, KE;
Indirizzi:
Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 Therapeut, Kansas City, KS 66160 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 303, anno: 2001,
pagine: 9 - 12
SICI:
0304-3940(20010427)303:1<9:DDRIRS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESTLESS LEGS SYNDROME; LIMB MOVEMENTS; ANTINOCICEPTION; TRANSMISSION; PRAMIPEXOLE; INVOLVEMENT; RELEVANCE; LIGAND; BRAIN;
Keywords:
spinal cord; rat; D-3 dopamine receptor; D-2-like dopamine receptor; D-1-like dopamine receptor; receptor autoradiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Levant, B Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, 3901 Rainbow Blvd, Kansas City, KS 66160 USA Univ Kansas 3901 Rainbow Blvd KansasCity KS USA 66160 66160 USA
Citazione:
B. Levant e K.E. McCarson, "D-3 dopamine receptors in rat spinal cord: implications for sensory and motor function", NEUROSCI L, 303(1), 2001, pp. 9-12

Abstract

Quantitative autoradiography was used to determine the distribution of D-3receptors in rat spinal cord and compare it with the distribution of D-1-like and D-2 (and D-4) receptors. [H-3]PD 128907-labeled D-3 sites were observed in roughly 6-fold lower density than [H-3]spiperone-labeled D-2 (D-4) sites and 60-fold lower density than [H-3]SCH 23390-labeled D-1-like sites. Highest densities of Dg binding were observed in the superficial layers ofthe dorsal horn at cervical and lumbar levels followed by the pars centralis and dorsal horn. Lowest densities of D-3 sites were detected in the ventral horn. These observations suggest that spinal D-3 receptors may play a role in sensory and/or motor function or contribute to the pharmacological effects of dopaminergic drugs. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:21:22