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Titolo:
Nociceptin/orphanin FQ inhibits stress- and CRF-induced anorexia in rats
Autore:
Ciccocioppo, R; Martin-Fardon, R; Weiss, F; Massi, M;
Indirizzi:
Univ Camerino, Dept Pharmacol Sci & Expt Med, I-62032 Camerino, Italy UnivCamerino Camerino Italy I-62032 & Expt Med, I-62032 Camerino, Italy Scripps Clin & Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 col, La Jolla, CA 92037 USA
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 12, anno: 2001,
pagine: 1145 - 1149
SICI:
0959-4965(20010508)12:6<1145:NFISAC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; CENTRAL-NERVOUS-SYSTEM; ORPHANIN-FQ; BEHAVIORAL-RESPONSES; RECEPTOR; FQ/NOCICEPTIN; PHARMACOLOGY; LOCALIZATION; NEUROPEPTIDE; AGONIST;
Keywords:
corticotropin releasing factor; electric footshock; nociceptin; ORLI receptors; orphanin FQ; restraint; rat; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Ciccocioppo, R Univ Camerino, Dept Pharmacol Sci & Expt Med, I-62032 Camerino, Italy Univ Camerino Camerino Italy I-62032 2032 Camerino, Italy
Citazione:
R. Ciccocioppo et al., "Nociceptin/orphanin FQ inhibits stress- and CRF-induced anorexia in rats", NEUROREPORT, 12(6), 2001, pp. 1145-1149

Abstract

The purpose of this study was to examine whether nociceptin/orphanin FQ (NC), the endogenous ligand of the opioid receptor-like 1 (ORLI) receptor, isable to block hypophagia induced by either stress or central administration of corticotropin releasing factor (CRF) in rats. A marked reduction in food consumption was observed following exposure to 15 min intermittent electric footshock 60 min physical immobilization or after intracerebroventricular (i.c.v.) injection of CRF (0.1-1.01 mug/rat). i.c.v, pretreatment with NC (0.1-2.0 mug/rat) completely abolished the hypophagic effect induced by stress or by i.c.v. CRF injection. The same i.c.v. doses of NC did not modify food consumption in food deprived rats and did not modify the anorexic effect induced by lipopolysaccharide, suggesting that the effect of NC is selective for anorexia induced by stress or CRF. These findings provide original evidence that NC attenuates stress-induced anorexia, presumably by acting as a functional CRF antagonist. NeuroReport 12:1145-1149 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:50:24