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Titolo:
Phenytoin inhibits isolation-induced aggression specifically in rats with low serotonin
Autore:
Keele, NB;
Indirizzi:
Baylor Univ, Dept Psychol, Waco, TX 76798 USA Baylor Univ Waco TX USA 76798 ylor Univ, Dept Psychol, Waco, TX 76798 USA Baylor Univ, Dept Neurosci, Waco, TX 76798 USA Baylor Univ Waco TX USA 76798 lor Univ, Dept Neurosci, Waco, TX 76798 USA
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 12, anno: 2001,
pagine: 1107 - 1112
SICI:
0959-4965(20010508)12:6<1107:PIIASI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEHAVIOR; RECEPTOR; MODEL; CSF;
Keywords:
aggression; anticonvulsant; PCPA; phenytoin; rat; resident-intruder; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Keele, NB Baylor Univ, Dept Psychol, Box 97334, Waco, TX 76798 USA Baylor Univ Box 97334 Waco TX USA 76798 7334, Waco, TX 76798 USA
Citazione:
N.B. Keele, "Phenytoin inhibits isolation-induced aggression specifically in rats with low serotonin", NEUROREPORT, 12(6), 2001, pp. 1107-1112

Abstract

Phenytoin is a widely used anticonvulsant drug that also reduces aggressive behavior. Aggression in humans and animals is often associated with low serotonin levels. This study examined the anti-aggressive properties of phenytoin in rodent isolation-induced aggression using a resident-intruder testto quantify aggression. Chronic treatment with p-chlorophenylalanine (PCPA), a competitive inhibitor of serotonin synthesis, significantly enhanced resident attack behavior compared to saline-treated control rats. Phenytoin dose-dependently reduced aggressive behavior specifically in PCPA-treated rats, but had no anti-aggressive properties in saline-treated rats. These data suggest that aggressive behavior in this model may be related to neuronal hyperexcitability that is sensitive to the anticonvulsant effects of phenytoin. Further, these data suggest isolation-induced aggression in PCPA-treated rats may be a useful model to investigate aggression associated with low serotonin in the brain. NeuroReport 12:1107-1112 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 30/03/20 alle ore 08:45:34