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Titolo:
Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts
Autore:
Szeto, CYK; Tang, NLS; Lee, DTS; Stadlin, A;
Indirizzi:
Chinese Univ Hong Kong, Dept Anat, Sha Tin, Hong Kong, Peoples R China Chinese Univ Hong Kong Sha Tin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Dept Chem Pathol, Sha Tin, Hong Kong, Peoples R China Chinese Univ Hong Kong Sha Tin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Dept Psychiat, Sha Tin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong Sha Tin Hong Kong Peoples R China Peoples R China
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 12, anno: 2001,
pagine: 1103 - 1106
SICI:
0959-4965(20010508)12:6<1103:ABMORG>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-ABUSE; BETA-ENDORPHIN; KNOCKOUT MICE; ALCOHOL; DEPENDENCE; BINDING; LACKING;
Keywords:
addiction; gene polymorphism; heroin; mu opioid receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Stadlin, A Chinese Univ Hong Kong, Dept Anat, Sha Tin, Hong Kong, Peoples R China Chinese Univ Hong Kong Sha Tin Hong Kong Peoples R China hina
Citazione:
C.Y.K. Szeto et al., "Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts", NEUROREPORT, 12(6), 2001, pp. 1103-1106

Abstract

Mu opioid receptor (MOR) has been shown to be associated with alcoholism and opioid dependence. The present study examined the involvement of a polymorphism in A118G in exon 1 and C1031G in intron 2 of the MOR gene in 200 Chinese heroin-dependent and 97 control subjects. Results showed a significant association for both Al 18G and C1031G polymorphisms and opioid dependence. The G allele is more common in the heroin-dependent group (39.5% and 30.8% for Al 18G and C1031G polymorphisms, respectively) when compared to the controls (29.4% and 21.1% for A118G and C1031G polymorphisms, respectively). This study suggests that the variant G allele of both A118G and C1031G polymorphisms may contribute to the vulnerability to heroin dependence. NeuroReport 12:1103-1106 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:38:15