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Titolo:
Conversion of brain apolipoprotein E to an insoluble form in a mouse modelof Alzheimer disease
Autore:
Naidu, A; Catalano, R; Bales, K; Wu, S; Paul, SM; Cordell, B;
Indirizzi:
Scios Inc, Sunnyvale, CA 94085 USA Scios Inc Sunnyvale CA USA 94085Scios Inc, Sunnyvale, CA 94085 USA Lilly Res Labs, Neurosci Discovery Res, Indianapolis, IN 46285 USA Lilly Res Labs Indianapolis IN USA 46285 Res, Indianapolis, IN 46285 USA
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 12, anno: 2001,
pagine: 1265 - 1270
SICI:
0959-4965(20010508)12:6<1265:COBAET>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; BETA-PEPTIDE DEPOSITION; TRANSGENIC MICE; E GENOTYPE; PROGRESSION; COMPLEXES; CORTEX; ROLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Cordell, B Scios Inc, 820 W Maude Ave, Sunnyvale, CA 94085 USA Scios Inc 820 W Maude Ave Sunnyvale CA USA 94085 , CA 94085 USA
Citazione:
A. Naidu et al., "Conversion of brain apolipoprotein E to an insoluble form in a mouse modelof Alzheimer disease", NEUROREPORT, 12(6), 2001, pp. 1265-1270

Abstract

A beta deposition in the APP(V717F) transgenic model of Alzheimer's pathology involves apolipoprotein E (apoE). We measured soluble and insoluble apoE in brain region extracts at an early and late stage of plaque development. The apoE levels in the insoluble fraction were greatly elevated in the hippocampus and colter of aged transgenic animals but were unchanged in wild type or young APP(V717F) animals. Soluble apoE levels were unaltered. A beta levels were also measured and a positive correlation between apoE and A beta in the insoluble fraction was observed. ApoE transcription was increased similar to3-fold in the hippocampus of 17-month-old APP(V717F) mice, suggesting a region-specific upregulation of apoE transcription in the brains of APP(V717F) mice to compensate for apoE sequestered with fibrillar A beta. NeuroReport 12:1265-1270 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:41:11