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Titolo:
Human neural stem cells improve cognitive function of aged brain
Autore:
Qu, T; Brannen, CL; Kim, HM; Sugaya, K;
Indirizzi:
Univ Illinois, Inst Psychiat, Dept Psychiat, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 , Dept Psychiat, Chicago, IL 60612 USA
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 12, anno: 2001,
pagine: 1127 - 1132
SICI:
0959-4965(20010508)12:6<1127:HNSCIC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; NEURODEGENERATIVE DISEASE; GLIAL-CELLS; TRANSPLANTATION; GROWTH; DIFFERENTIATION; NEUROGENESIS; HIPPOCAMPUS; MIGRATION; ASTROCYTES;
Keywords:
aging; differentiation; engraftment; memory; migration; progenitor; transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Sugaya, K Univ Illinois, Inst Psychiat, Dept Psychiat, 1601 W Taylor St, Chicago, IL60612 USA Univ Illinois 1601 W Taylor St Chicago IL USA 60612 IL60612 USA
Citazione:
T. Qu et al., "Human neural stem cells improve cognitive function of aged brain", NEUROREPORT, 12(6), 2001, pp. 1127-1132

Abstract

The capability for in vitro expansion of human neural stem cells (HNSCs) provides a well characterized and unlimited source alternative to using primary fetal tissue for neuronal replacement therapies. The HNSCs, injected into the lateral ventricle of 24-month-old rats after in vitro expansion, displayed extensive and positional incorporation into the aged host brain withimprovement of cognitive score assessed by the Morris water maze after 4 weeks of the transplantation. Our results demonstrate that the aged brain iscapable of providing the necessary environment for HNSCs to retain their pluripotent status and suggest the potential for neuroreplacement therapies in age-associated neurodegenerative disease. NeuroReport 12:1127-1132 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 02/04/20 alle ore 19:21:57