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Titolo:
Corticosterone-aggravated ischemic neuronal damage in vitro is relieved byvanadate
Autore:
Payne, RS; Schurr, A;
Indirizzi:
Univ Louisville, Sch Med, Dept Anesthesiol, Brain Attack Res Lab, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 Res Lab, Louisville, KY 40292 USA Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 Toxicol, Louisville, KY 40292 USA
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 12, anno: 2001,
pagine: 1261 - 1263
SICI:
0959-4965(20010508)12:6<1261:CINDIV>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-METABOLISM; INSULIN-RECEPTOR; BRAIN; RATS; HIPPOCAMPUS;
Keywords:
corticosterone; hippocampal slice; ischemia; neuronal damage; vanadate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Schurr, A Univ Louisville, Sch Med, Dept Anesthesiol, Brain Attack Res Lab, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 ouisville, KY 40292 USA
Citazione:
R.S. Payne e A. Schurr, "Corticosterone-aggravated ischemic neuronal damage in vitro is relieved byvanadate", NEUROREPORT, 12(6), 2001, pp. 1261-1263

Abstract

Preischemic hyperglycemia-aggravated neuronal damage has been postulated to occur via enhanced lactic acidosis. We have hypothesized that preischemicglucose loading induces a short-lived elevation in glucocorticoid release which, when combined with ischemia, aggravates the postischemic outcome. This study tested this hypothesis in rat hippocampal slices exposed to 4 min in vitro ischemia of which 58% exhibited recovery of neuronal function. However, when corticosterone (CT) was present during ischemia, the recovery ofneuronal function decreased in a concentration-dependent manner. At 5 muM,CT reduced the recovery rate to 40% while only 10% of slices recovered when exposed to 20 muM CT. Insulin could not block the effect of CT; however, vanadate improved the postischemic recovery of CT-treated (20 muM) slices to 43%. These results indicate that acute, short exposure to CT can significantly exacerbate postischemic outcome and that vanadate can antagonize CT action. NeuroReport 12:1261-1263 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 25/01/20 alle ore 18:58:19