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Titolo:
Fluoxetine reduces L-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum?
Autore:
Yamato, H; Kannari, K; Shen, H; Suda, T; Matsunaga, M;
Indirizzi:
Hirosaki Univ, Sch Med, Inst Neurol Dis, Dept Neurol, Hirosaki, Aomori 0368216, Japan Hirosaki Univ Hirosaki Aomori Japan 0368216 rosaki, Aomori 0368216, Japan Hirosaki Univ, Sch Med, Dept Med 3, Hirosaki, Aomori 0368216, Japan Hirosaki Univ Hirosaki Aomori Japan 0368216 rosaki, Aomori 0368216, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 12, anno: 2001,
pagine: 1123 - 1126
SICI:
0959-4965(20010508)12:6<1123:FRLEDI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; IN-VIVO; REUPTAKE INHIBITOR; 5-HT1A; BRAIN; 5-HYDROXYTRYPTAMINE; MICRODIALYSIS; DEPRESSION; AGONISTS; ANTIDEPRESSANT;
Keywords:
L-DOPA; dopamine; fluoxetine; 6-hydroxydopamine; microdialysis; Parkinson's disease; rat; serotonin; SSRI; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Kannari, K Hirosaki Univ, Sch Med, Inst Neurol Dis, Dept Neurol, 5 Zaifu-cho, Hirosaki, Aomori 0368216, Japan Hirosaki Univ 5 Zaifu-cho Hirosaki Aomori Japan 0368216 , Japan
Citazione:
H. Yamato et al., "Fluoxetine reduces L-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum?", NEUROREPORT, 12(6), 2001, pp. 1123-1126

Abstract

We investigated the effect of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), on L-DOPA-derived extracellular dopamine (DA) levels in the striatum of rats with nigrostriatal dopaminergic denervation using in vivo microdialysis. Treatment with fluoxetine (10 mg/kg, i.p.) induced a 41% reduction in the cumulative amount of extracellular DA during 300 min following L-DOPA administration (50 mg/kg, i.p.; p < 0.01). This effect was antagonized by pretreatment with WAY-100635, a potent 5-HTIA antagonist, indicating that this effect of fluoxetine is due to its indirect 5-HTIA agonistic property. These results suggest that SSRls may impair motor functions in patients with Parkinson's disease by reducing efflux of exogenous L-DOPA-derived DA. NeuroReport 12:1123-1126 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:19:07