Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nitrotyrosination contributes minimally to toxicity of mutant SOD1 associated with ALS
Autore:
Doroudchi, MM; Minotti, S; Figlewicz, DA; Durham, HD;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 Inst, Montreal, PQ H3A 2B4, Canada McGill Univ, Dept Neurol Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada Univ Rochester, Dept Neurol, Rochester, NY USA Univ Rochester Rochester NY USA ochester, Dept Neurol, Rochester, NY USA Univ Rochester, Dept Neurobiol & Anat, Rochester, NY USA Univ Rochester Rochester NY USA Dept Neurobiol & Anat, Rochester, NY USA
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 12, anno: 2001,
pagine: 1239 - 1243
SICI:
0959-4965(20010508)12:6<1239:NCMTTO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; CU/ZN-SUPEROXIDE-DISMUTASE; NITRIC-OXIDE SYNTHASE; MOTOR-NEURON TOXICITY; TYROSINE NITRATION; TRANSGENIC MICE; DEATH; PEROXYNITRITE; MECHANISMS; MUTATIONS;
Keywords:
amyotrophic lateral sclerosis; Cu/Zn-superoxide dismutase; motor neuron; neuroprotection; neurotoxicity; nitric oxide synthase; nitrotyrosine; SOD1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Durham, HD McGill Univ, Montreal Neurol Inst, 3801 Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St Montreal PQ Canada H3A 2B4 2B4, Canada
Citazione:
M.M. Doroudchi et al., "Nitrotyrosination contributes minimally to toxicity of mutant SOD1 associated with ALS", NEUROREPORT, 12(6), 2001, pp. 1239-1243

Abstract

Enhanced production of nitrotyrosine and subsequent protein nitration has been proposed as the mechanism by which mutant SODI causes death of motor neurons in a familiar form of amyotrophic lateral sclerosis (FALS-I). We have tested this hypothesis in a primary culture model in which mutant human SODI was expressed in motor neurons of dissociated spinal cord cultures. Preventing formation of nitrotyrosine by inhibiting nitric oxide synthase rescued cultured motor neurons from excitotoxic death induced by adding glutamate to the culture medium, but failed to significantly delay death of motor neurons expressing the G93A mutant SODI. The results do not support generation of nitrotyrosine being the predominant lethal gain of function conferred by mutations in SODI. NeuroReport 12: 1243-1243 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:00:15