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Titolo:
Novel splice variants of PACAP gene in mouse cerebellar granule cells
Autore:
Tabuchi, A; Koizumi, M; Tsuda, M;
Indirizzi:
Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Biol Chem, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan Sci & Technol Corp Japan, CREST, Tsukuba, Ibaraki, Japan Sci & Technol Corp Japan Tsukuba Ibaraki Japan , Tsukuba, Ibaraki, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 12, anno: 2001,
pagine: 1181 - 1186
SICI:
0959-4965(20010508)12:6<1181:NSVOPG>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLASE-ACTIVATING POLYPEPTIDE; ADENYLATE-CYCLASE; BDNF; TRANSCRIPTION;
Keywords:
alternative splicing; cerebellar granule cells; L-type voltage-dependent Ca2+ channel; pituitary adenylate cyclase activating polypeptide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuda, M Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Biol Chem,Sugitani2630, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Sugitani 2630 Toyama Japan 9300194
Citazione:
A. Tabuchi et al., "Novel splice variants of PACAP gene in mouse cerebellar granule cells", NEUROREPORT, 12(6), 2001, pp. 1181-1186

Abstract

The mouse pituitary adenylate cyclase activating polypeptide (PACAP) gene consists of two alternative exons (IA and IB) and four exons including the coding region. By the usage of alternative exons, three transcripts can be produced. In this report, however, we found that at least five preproPACAP transcripts, including two novel types, were produced in mouse cerebellar granule cells (CGCs) and their expression was induced by the Ca2+ influx through L-type voltage-dependent Ca2+ channels. The splicing occurred between the 3'-donor site of exon IA and the Mo novel internal 5'-acceptor sites ofexon IB. These findings suggest that preproPACAP transcripts are produced by the complicated usage of the 5'-untranslated region in an activity-dependent manner. NeuroReport 12:1181-1186 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:15:59