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Titolo:
The mineralocorticoid receptor expression in the mouse CNS is conserved during development
Autore:
Kretz, O; Schmid, W; Berger, S; Gass, P;
Indirizzi:
German Canc Res Ctr, Dept Mol Biol Cell I, D-6900 Heidelberg, Germany German Canc Res Ctr Heidelberg Germany D-6900 D-6900 Heidelberg, Germany Cent Inst Mental Hlth, D-68159 Mannheim, Germany Cent Inst Mental Hlth Mannheim Germany D-68159 D-68159 Mannheim, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 12, anno: 2001,
pagine: 1133 - 1137
SICI:
0959-4965(20010508)12:6<1133:TMREIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; GLUCOCORTICOID RECEPTOR; RAT-BRAIN; IMMUNOREACTIVE NEURONS; COMPLEMENTARY-DNA; CORTICOSTERONE; HIPPOCAMPUS; CLONING; INVITRO; CELLS;
Keywords:
development; immunocytochemistry; mineralocorticoid receptor; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Gass, P German Canc Res Ctr, Dept Mol Biol Cell I, D-6900 Heidelberg, Germany German Canc Res Ctr Heidelberg Germany D-6900 eidelberg, Germany
Citazione:
O. Kretz et al., "The mineralocorticoid receptor expression in the mouse CNS is conserved during development", NEUROREPORT, 12(6), 2001, pp. 1133-1137

Abstract

Using a specific polyclonal antiserum raised in rabbit against amino acids1-23 of the mouse mineralocorticoid receptor (MR) we investigated the developmental profile of MR expression in the murine CNS by immunocytochemistry. MR protein appeared first at embryonic day E16.5 in the limbic system, i.e. in the hippocampus and induseum griseum. During development and in adulthood, high levels of MR expression were observed in the limbic system, whereas expression levels detectable in layers II, III, V of the neocortex and in motoneurons of cranial nerves and spinal cord were lower. No MR stainingwas found in the hypothalamus. Developmental MR expression was restricted to neuronal populations that also express MR protein in the adult CNS, indicating that the MR may fulfill the same functions in neurons during development and in adulthood. NeuroReport 12:1133-1137 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:18:35