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Titolo:
Chronic effects of triiodothyronine in combination with imipramine on 5-HTtransporter, 5-HT1A and 5-HT2A receptors in adult rat brain
Autore:
Moreau, X; Jeanningros, R; Mazzola-Pomietto, P;
Indirizzi:
Fac Med Nord, INSERM U501, F-13916 Marseille 20, France Fac Med Nord Marseille France 20 SERM U501, F-13916 Marseille 20, France
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 6, volume: 24, anno: 2001,
pagine: 652 - 662
SICI:
0893-133X(200106)24:6<652:CEOTIC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIDEPRESSANT DRUG-TREATMENT; H-3 PAROXETINE BINDING; SEROTONIN UPTAKE SITES; THYROID-HORMONE; FRONTAL-CORTEX; MESSENGER-RNA; IN-VIVO; DEPRESSION; POTENTIATION; FLUOXETINE;
Keywords:
5-HT transporter; 5-HT1A receptor; 5-HT2A receptor; tricyclic antidepressant; triiodothyronine; brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Mazzola-Pomietto, P Fac Med Nord, INSERM U501, Blvd Pierre Dramard, F-13916 Marseille 20, France Fac Med Nord Blvd Pierre Dramard Marseille France 20
Citazione:
X. Moreau et al., "Chronic effects of triiodothyronine in combination with imipramine on 5-HTtransporter, 5-HT1A and 5-HT2A receptors in adult rat brain", NEUROPSYCH, 24(6), 2001, pp. 652-662

Abstract

Triiodothyronine (T3) has been shown to accelerate and potentiate the clinical response to tricyclic antidepressant (TCA) treatment in depressive disorders. The neurobiological mechanism underlying these therapeutic effects of T3 are still unknown. Since brain serotonin (5-HT) changes have been implicated in the mode of action of TCA drugs, the effects of a chronic (7 or 21 days) administration of imipramine (10 mg/kg/day) and of a low dose of T3 (4 mug/kg/day), given alone or in combination, were investigated on the density of midbrain 5-HT transporters and of hippocampal 5-HT1A and cortical5-HT2A receptors in adult Wistar rats. Neither single nor combined administration of imipramine and T3 for 7 days modified the density of 5-HT transporters and of 5-HT1A receptors. On day 21, the combination did not change imipramine- or T3-induced decrease in 5-HT transporter density whereas it prevented imipramine-induced increased in 5-HT1A receptor density. Whatever the treatment duration, imipramin-T3 combination potentiated imipramine-induced decrease in 5-HT2A receptor density. On both day 7 and 21, T3 given alone had no effects on the density of 5-HT1A and 5-HT2A receptors. These dataindicate that T3 is able to modulate the long-term adaptive changes which occur at the postsynaptic level of 5-HT neurotransmission after antidepressant treatment. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:54:40