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Titolo:
Paradoxical hormonal and behavioral responses to hypo-thyroid and hyperthyroid states in the Wistar-Kyoto rat
Autore:
Redei, EE; Solberg, LC; Kluczynski, JM; Pare, WP;
Indirizzi:
Northwestern Univ, Sch Med, Dept Psychiat & Behav Sci, Asher Ctr Study & Treatment Depress Disorders, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 s Disorders, Chicago, IL 60611 USA Vet Adm Med Ctr, Perry Point, MD USA Vet Adm Med Ctr Perry Point MD USAVet Adm Med Ctr, Perry Point, MD USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 6, volume: 24, anno: 2001,
pagine: 632 - 639
SICI:
0893-133X(200106)24:6<632:PHABRT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; FORCED SWIMMING TEST; WKY RATS; LEARNED HELPLESSNESS; ANIMAL-MODEL; INDUCED REVERSAL; STRESS-RESPONSE; INBRED STRAINS; DEPRESSION; BRAIN;
Keywords:
T-3; depression model; open field test; forced swim test; strains;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Redei, EE Northwestern Univ, Sch Med, Dept Psychiat & Behav Sci, Asher CtrStudy & Treatment Depress Disorders, 303 E Chicago Ave,Ward 9-198, Chicago, IL 60611USA Northwestern Univ 303 E Chicago Ave,Ward 9-198 Chicago IL USA60611
Citazione:
E.E. Redei et al., "Paradoxical hormonal and behavioral responses to hypo-thyroid and hyperthyroid states in the Wistar-Kyoto rat", NEUROPSYCH, 24(6), 2001, pp. 632-639

Abstract

Wistar-Kyoto (WKY) rats show endogenous depressive behavior that can be reversed by antidepressants. Given that WKYs exhibit decreased sensitivity tosome antidepressants and treatment-resistant depressed patients often showhypothalamic-pituitary-thyroid (HPT) dysregulation, we examined the behavioral and HPT hormonal responses of WKYs to altered thyroid status. "Euthyroid" WKYs had elevated basal plasma TSH and T-3 levels as compared to Wistars. Hypothyroidism increased TSH levels more in WKYs than in Wistars and increased response latency in the open field test (OFT) of WKYs only. Administration of T-4 and T-3 suppressed plasma TSH equally in both strains. Wistars responded to increased T-3 levels with decreased response latency and increased activity in the OFT, but increased immobility in the forced swim test. In contrast, WKYs responded only to the high T-3 levels with decreased response latency in the OFT. These results suggest the existence of a decreased central nervous system sensitivity to thyroid hormones in WKYs that could be related to their depressive behavior. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 05/04/20 alle ore 19:29:49