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Titolo:
Seasonal affective disorder and serotonin-related polymorphisms
Autore:
Johansson, C; Smedh, C; Partonen, T; Pekkarinen, P; Paunio, T; Ekholm, J; Peltonen, L; Lichtermann, D; Palmgren, J; Adolfsson, R; Schalling, M;
Indirizzi:
Karolinska Inst, Dept Mol Med, Neurogenet Unit, Karolinska Hosp, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Hosp, S-17176 Stockholm, Sweden Umea Univ, Div Psychiat, Dept Clin Sci, S-90185 Umea, Sweden Umea Univ Umea Sweden S-90185 chiat, Dept Clin Sci, S-90185 Umea, Sweden Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, FIN-00300 Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland FIN-00300 N-00300 Helsinki, Finland Natl Publ Hlth Inst, Dept Human Mol Genet, FIN-00300 Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland FIN-00300 N-00300 Helsinki, Finland Univ Helsinki, Dept Med Genet, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 et, FIN-00014 Helsinki, Finland Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 onn, Dept Psychiat, D-53105 Bonn, Germany Stockholm Univ, Dept Math Stat, S-10691 Stockholm, Sweden Stockholm Univ Stockholm Sweden S-10691 Stat, S-10691 Stockholm, Sweden Karolinska Inst, Dept Med Epidemiol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 miol, S-17177 Stockholm, Sweden
Titolo Testata:
NEUROBIOLOGY OF DISEASE
fascicolo: 2, volume: 8, anno: 2001,
pagine: 351 - 357
SICI:
0969-9961(200104)8:2<351:SADASP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRYPTOPHAN-HYDROXYLASE GENE; REPEAT LENGTH POLYMORPHISM; ANXIETY-RELATED TRAITS; BRIGHT LIGHT THERAPY; TRANSPORTER GENE; PROMOTER POLYMORPHISM; 5-HT2A RECEPTOR; FUNCTIONAL POLYMORPHISM; REGULATORY REGION; ASSOCIATION;
Keywords:
depression; seasonality; serotonin transporter; serotonin receptor 2A; serotonin receptor 2C; tryptophan hydroxylase; white; association study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Johansson, C Karolinska Inst, Dept Mol Med, Neurogenet Unit, Karolinska Hosp, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Stockholm, Sweden
Citazione:
C. Johansson et al., "Seasonal affective disorder and serotonin-related polymorphisms", NEUROBIOL D, 8(2), 2001, pp. 351-357

Abstract

Disturbances in central serotonergic systems have been hypothesized to be involved in seasonal affective disorder (SAD). Association between SAD and the shorter allele of the serotonin transporter promoter repeat length polymorphism (5-HTTLPR) has been reported in an American sample. We have genotyped 82 SAD patients and 82 healthy controls from Sweden, Finland, and Germany for this and five other polymorphisms in the genes coding for serotonin receptors 5-HT2A and 5-HT2C, tryptophan hydroxylase and white. No associations with SAD or seasonality (seasonal variations in mood and behavior) weredetected. Although minor effects cannot be excluded, our results suggest that these polymorphisms do not play a major role in the pathogenesis of SADin the northern European population. (C) 2001 Academic Press.

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Documento generato il 11/07/20 alle ore 11:25:03